The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function

TNFRSF13B, which encodes TACI (transmembrane activator and calcium-modulator and cyclophilin ligand interactor), is mutated in 10% of patients with common variable immune deficiency (CVID). One of the 2 most common TACI mutations in CVID, A181E, introduces a negative charge into the transmembrane do...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 2009-09, Vol.114 (11), p.2254-2262
Hauptverfasser:	Lee, John J., Rauter, Ingrid, Garibyan, Lilit, Ozcan, Esra, Sannikova, Tatyana, Dillon, Stacey R., Cruz, Anthony C., Siegel, Richard M., Bram, Richard, Jabara, Haifa, Geha, Raif S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals B-Lymphocytes - immunology Biological and medical sciences Common Variable Immunodeficiency - genetics Common Variable Immunodeficiency - immunology Common Variable Immunodeficiency - metabolism Ficoll - analogs & derivatives Ficoll - pharmacology Fluorescence Resonance Energy Transfer Hematologic and hematopoietic diseases Humans Immunobiology Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunoglobulin A - blood Immunoglobulin A - immunology Immunoglobulin G - blood Immunoglobulin G - immunology Immunopathology Medical sciences Mice Mice, Knockout Mutation, Missense NF-kappa B - genetics NF-kappa B - immunology NF-kappa B - metabolism Protein Structure, Tertiary - genetics Signal Transduction - genetics Signal Transduction - immunology Transmembrane Activator and CAML Interactor Protein - genetics Transmembrane Activator and CAML Interactor Protein - immunology Transmembrane Activator and CAML Interactor Protein - metabolism Trinitrobenzenes - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!