The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue

Fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients share many similarities with transformed cancer cells, including spontaneous production of matrix metalloproteinases (MMPs). Altered or chronic activation of proto-oncogenic Ras family GTPases is thought to contribute to infl...

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Veröffentlicht in:	Arthritis research & therapy 2009-01, Vol.11 (4), p.R121-R121, Article R121
Hauptverfasser:	Abreu, Joana R F, de Launay, Daphne, Sanders, Marjolein E, Grabiec, Aleksander M, van de Sande, Marleen G, Tak, Paul P, Reedquist, Kris A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Arthritis, Rheumatoid - metabolism Blotting, Western Cells, Cultured Enzyme-Linked Immunosorbent Assay Female Fibroblasts - metabolism Fluorescent Antibody Technique Gene Expression Gene Expression Regulation - physiology Gene mutations Genetic aspects Guanosine triphosphatase Humans Image Processing, Computer-Assisted Immunohistochemistry Male Matrix Metalloproteinase 1 - biosynthesis Matrix Metalloproteinase 3 - biosynthesis Middle Aged Nucleotides Phenotype ras-GRF1 - genetics ras-GRF1 - metabolism Rheumatoid arthritis Synovial fluid Synovial Membrane - metabolism Transfection
Online-Zugang:	Volltext
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