Association between ADORA2A and DRD2 Polymorphisms and Caffeine-Induced Anxiety

Caffeine produces mild psychostimulant and sometimes anxiogenic effects by antagonizing adenosine at A 1 and A 2A receptors, and perhaps through interactions with other transmitter systems. Adenosine receptors are colocalized and functionally interact with dopamine receptors in the brain. Thus, func...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2008-11, Vol.33 (12), p.2791-2800
Hauptverfasser:	Childs, Emma, Hohoff, Christa, Deckert, Jürgen, Xu, Ke, Badner, Judith, de Wit, Harriet
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - metabolism Adolescent Adult Anxiety Anxiety Disorders - chemically induced Anxiety Disorders - genetics Anxiety Disorders - physiopathology Behavioral Sciences Biological and medical sciences Biological Psychology Brain - drug effects Brain - metabolism Brain - physiopathology Brain Chemistry - drug effects Brain Chemistry - genetics Caffeine - toxicity DNA Mutational Analysis Dopamine - metabolism Dose-Response Relationship, Drug Female Genetic Predisposition to Disease - genetics Genetic Testing Genetic Variation - genetics Genotype Humans Male Medical sciences Medicine Medicine & Public Health Neuropharmacology Neurosciences original-article Pharmacology. Drug treatments Pharmacotherapy Phosphodiesterase Inhibitors - pharmacology Polymorphism, Genetic Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Receptor, Adenosine A2A - drug effects Receptor, Adenosine A2A - genetics Receptors, Dopamine D2 - drug effects Receptors, Dopamine D2 - genetics Self-Assessment Young Adult
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