Development and Cancer: At the Crossroads of Nodal and Notch Signaling
Aggressive tumor cells express a plastic, multipotent phenotype similar to embryonic stem cells. However, the absence of major regulatory checkpoints in these tumor cells allows aberrant activation of embryonic signaling pathways, which seems to contribute to their plastic phenotype. Emerging eviden...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2009-09, Vol.69 (18), p.7131-7134 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | STRIZZI, Luigi HARDY, Katharine M SEFTOR, Elisabeth A COSTA, Fabricio F KIRSCHMANN, Dawn A SEFTOR, Richard E. B POSTOVIT, Lynne-Marie HENDRIX, Mary J. C |
| description | Aggressive tumor cells express a plastic, multipotent phenotype similar to embryonic stem cells. However, the absence of major regulatory checkpoints in these tumor cells allows aberrant activation of embryonic signaling pathways, which seems to contribute to their plastic phenotype. Emerging evidence showing the molecular cross-talk between two major stem cell signaling pathways Nodal and Notch suggests a promising therapeutic strategy that could target aggressive tumor cells on the basis of their unique plasticity, and provide new insights into the mechanisms underlying the re-emergence of developmental signaling pathways during tumor progression. |
| doi_str_mv | 10.1158/0008-5472.can-09-1199 |
| format | Article |
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| ispartof | Cancer research (Chicago, Ill.), 2009-09, Vol.69 (18), p.7131-7134 |
| issn | 0008-5472 1538-7445 |
| language | eng |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antineoplastic agents Biological and medical sciences Humans Medical sciences Neoplasms - metabolism Neoplasms - pathology Nodal Protein - metabolism Pharmacology. Drug treatments Receptors, Notch - metabolism Signal Transduction Tumors |
| title | Development and Cancer: At the Crossroads of Nodal and Notch Signaling |
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