Levels of Prostaglandin E Metabolite and Leukotriene E4 Are Increased in the Urine of Smokers: Evidence that Celecoxib Shunts Arachidonic Acid into the 5-Lipoxygenase Pathway

Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) play a role in inflammation and carcinogenesis. Biomarkers that reflect tobacco smoke–induced tissue injury are needed. In this study, levels of urinary prostaglandin E metabolite (PGE-M) and leukotriene E4 (LTE4), biomarkers of the COX and 5-LO pat...

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Veröffentlicht in:	Cancer prevention research (Philadelphia, Pa.) Pa.), 2009-04, Vol.2 (4), p.322-329
Hauptverfasser:	Duffield-Lillico, Anna J., Boyle, Jay O., Zhou, Xi Kathy, Ghosh, Aradhana, Butala, Geera S., Subbaramaiah, Kotha, Newman, Robert A., Morrow, Jason D., Milne, Ginger L., Dannenberg, Andrew J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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