Familial risk for Alzheimer's disease alters fMRI activation patterns

Alzheimer's disease poses a looming crisis for the health care system as well as society in general. The low efficacy of current treatments for those already affected with this disease has prompted the suggestion that interventions might be more successful if they were applied before the develo...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2006-05, Vol.129 (5), p.1229-1239
Hauptverfasser:	Bassett, Susan Spear, Yousem, David M., Cristinzio, Catherine, Kusevic, Ivana, Yassa, Michael A., Caffo, Brian S., Zeger, Scott L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Aged Alleles Alzheimer Disease - diagnosis Alzheimer Disease - genetics Alzheimer Disease - physiopathology Alzheimer's disease APOE = apolipoprotein E Apolipoprotein E4 Apolipoproteins E - genetics Association Learning Biological and medical sciences Brain - physiopathology Brain Mapping - methods Cross-Sectional Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Early Diagnosis familial Alzheimer's disease Female fMRI fMRI = functional magnetic resonance imaging Frontal Lobe - physiopathology Genetic Predisposition to Disease Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Magnetic Resonance Imaging Male Medical sciences Mental Recall Middle Aged MTL = medial temporal lobe Nervous system (semeiology, syndromes) Neurology Neuropsychological Tests pre-clinical changes SPM = statistical parametric mapping Temporal Lobe - physiopathology Thalamus - physiopathology
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