Akt and 14-3-3 Control a PACS-2 Homeostatic Switch that Integrates Membrane Traffic with TRAIL-Induced Apoptosis

TRAIL selectively kills diseased cells in vivo, spurring interest in this death ligand as a potential therapeutic. However, many cancer cells are resistant to TRAIL, suggesting the mechanism mediating TRAIL-induced apoptosis is complex. Here we identify PACS-2 as an essential TRAIL effector, require...

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Veröffentlicht in:	Molecular cell 2009-05, Vol.34 (4), p.497-509
Hauptverfasser:	Aslan, Joseph E., You, Huihong, Williamson, Danielle M., Endig, Jessica, Youker, Robert T., Thomas, Laurel, Shu, Hongjun, Du, Yuhong, Milewski, Robert L., Brush, Matthew H., Possemato, Anthony, Sprott, Kam, Fu, Haian, Greis, Kenneth D., Runckel, Douglas N., Vogel, Arndt, Thomas, Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - genetics 14-3-3 Proteins - metabolism Animals Apoptosis - physiology BH3 Interacting Domain Death Agonist Protein - genetics BH3 Interacting Domain Death Agonist Protein - metabolism Caspases - metabolism Cell Line, Tumor Cell Membrane - metabolism CELLBIO CELLCYCLE Cells, Cultured Fibroblasts - cytology Fibroblasts - metabolism Homeostasis Humans Mice Mice, Knockout Neoplasms - metabolism Neoplasms - pathology PROTEINS Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Serine - metabolism TNF-Related Apoptosis-Inducing Ligand - genetics TNF-Related Apoptosis-Inducing Ligand - metabolism Vesicular Transport Proteins - genetics Vesicular Transport Proteins - metabolism
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