Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial

Aims/hypothesis The aim of the study was to compare the efficacy and safety of liraglutide in type 2 diabetes mellitus vs placebo and insulin glargine (A21Gly,B31Arg,B32Arg human insulin), all in combination with metformin and glimepiride. Methods This randomised (using a telephone or web-based rand...

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Veröffentlicht in:	Diabetologia 2009-10, Vol.52 (10), p.2046-2055
Hauptverfasser:	Russell-Jones, D, Vaag, A, Schmitz, O, Sethi, B. K, Lalic, N, Antic, S, Zdravkovic, M, Ravn, G. M, Simó, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Blood Glucose - drug effects Body Weight Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes. Impaired glucose tolerance Disease Drug Therapy, Combination Endocrine pancreas. Apud cells (diseases) Endocrinology Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Glucagon Glucagon-Like Peptide 1 - analogs & derivatives Glucagon-Like Peptide 1 - therapeutic use Glucose Hepatitis Hospitals Human Physiology Humans Hypoglycemia Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Insulin - analogs & derivatives Insulin - therapeutic use Insulin Glargine Insulin resistance Insulin, Long-Acting Internal Medicine Liraglutide Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metformin - pharmacology Metformin - therapeutic use Middle Aged Peptides Placebos Sulfonylurea Compounds - pharmacology Sulfonylurea Compounds - therapeutic use Young Adult
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