Maintenance time of sedative effects after an intravenous infusion of diazepam： A guide for endoscopy using diazepam

AIM： To examine whether the sedative effects assessed by psychomotor tests would depend on the cytochrome P450 （CYP ） 2C19 genotypes after an infusion regimen of diazepam commonly used forgastrointestinal endoscopy in Japan. METHODS： Fifteen healthy Japanese volunteers consisting of three different...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2008-09, Vol.14 (33), p.5197-5203
Hauptverfasser:	Sugimoto, Mitsushige, Furuta, Takahisa, Nakamura, Akiko, Shirai, Naohito, Ikuma, Mutsuhiro, Misaka, Shingen, Uchida, Shinya, Watanabe, Hiroshi, Ohashi, Kyoichi, Ishizaki, Takashi, Hishida, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aryl Hydrocarbon Hydroxylases - genetics Cytochrome P-450 CYP2C19 Diazepam - administration & dosage Diazepam - adverse effects Diazepam - pharmacology Endoscopy, Gastrointestinal - methods Eye Movements - drug effects Eye Movements - physiology Female Flicker Fusion - drug effects Genotype Guidelines as Topic Humans Hypnotics and Sedatives - administration & dosage Hypnotics and Sedatives - adverse effects Hypnotics and Sedatives - pharmacology Infusions, Intravenous Male Posture - physiology Psychomotor Performance - drug effects Rapid Communication Time Factors 内窥镜检查法细胞色素P450 镇静作用静脉注射
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