Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells

AIM： To examine the ability of cyclin-dependent kinase inhibitor （CDKI） roscovitine （Rosco） to enhance the antitumor effects of conventional chemotherapeutic agents acting by different mechanisms against human colorectal cancer. METHODS： Human colorectal cancer cells were treated, individually and i...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2008-09, Vol.14 (33), p.5162-5175
Hauptverfasser:	Abaza, Mohamed Salah I, Bahman, Abdul-Majeed A, Al-Attiyah, Rajaa J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - pathology Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects Cell Cycle - drug effects Cell Line, Tumor Colorectal Cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology DNA Fragmentation - drug effects Dose-Response Relationship, Drug Doxorubicin - pharmacology Doxorubicin - therapeutic use Drug Synergism Drug Therapy, Combination Fluorouracil - pharmacology Fluorouracil - therapeutic use Humans Paclitaxel - pharmacology Paclitaxel - therapeutic use Purines - pharmacology Purines - therapeutic use Roscovitine Time Factors Vinblastine - pharmacology Vinblastine - therapeutic use 化学敏感作用协同作用直肠癌细胞凋亡细胞周期
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