Embryonic stem cell–specific microRNAs promote induced pluripotency

Judson et al . show that microRNAs specific to mouse embryonic stem cells can substitute for the reprogramming factor cMyc in the generation of induced pluripotent stem cells. The development of reprogramming methods that do not rely on transgenes may facilitate clinical translation of this technolo...

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Veröffentlicht in:	Nature biotechnology 2009-05, Vol.27 (5), p.459-461
Hauptverfasser:	Judson, Robert L, Babiarz, Joshua E, Venere, Monica, Blelloch, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animals Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology brief-communication Cell Dedifferentiation Cellular biology Embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Fundamental and applied biological sciences. Psychology Gene expression Genetic aspects Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Life Sciences Mice MicroRNAs - metabolism Miscellaneous Physiological aspects Pluripotent Stem Cells - metabolism Proto-Oncogene Proteins c-myc - metabolism Ribonucleic acid RNA Rodents Stem cells
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