An Evolutionary Perspective of Animal MicroRNAs and Their Targets
MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through translational inhibition or mRNA degradation by binding to sequences on the target mRNA. miRNA regulation appears to be the most abundant mode of posttranscriptional regulation affecting ∼50% of the transcriptome. miRN...
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Veröffentlicht in: | BioMed research international 2009-01, Vol.2009 (2009), p.1-9 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through translational inhibition or mRNA degradation by binding to sequences on the target mRNA. miRNA regulation appears to be the most abundant mode of posttranscriptional regulation affecting ∼50% of the transcriptome. miRNA genes are often clustered and/or located in introns, and each targets a variable and often large number of mRNAs. Here we discuss the genomic architecture of animal miRNA genes and their evolving interaction with their target mRNAs. |
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ISSN: | 1110-7243 2314-6133 1110-7251 2314-6141 |
DOI: | 10.1155/2009/594738 |