IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

The IQGAP family comprises three proteins in humans. The best characterized is IQGAP1, which participates in protein–protein interactions and integrates diverse signaling pathways. IQGAP2 and IQGAP3 harbor all the domains identified in IQGAP1, but their biological roles are poorly defined. Proteins...

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Veröffentlicht in:	FEBS letters 2009-06, Vol.583 (12), p.1817-1824
Hauptverfasser:	White, Colin D., Brown, Matthew D., Sacks, David B.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenomatous polyposis coli APC beta Catenin - metabolism Cancer casein kinase 1 Cell Adhesion Cell Movement Cell Proliferation CK1 ECM EGF epidermal growth factor ERK Exocytosis extracellular matrix extracellular signal-regulated kinase FGF fibroblast growth factor GAP Genes, Tumor Suppressor glycogen synthase kinase-3β GSK-3β GTPase-activating protein GTPase-Activating Proteins - chemistry GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism HCC hepatocellular carcinoma Humans IQGAP1 IQGAP2 IQGAP3 MAP Kinase Signaling System MAPK MAPK kinase matrix metalloproteinase MEK Metastasis mitogen-activated protein kinase MMP Molecular Structure Neoplasia Neoplasm Metastasis - genetics Neoplasm Metastasis - physiopathology Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms - etiology Neoplasms - genetics Neoplasms - metabolism Oncogenes Protein Binding Protein Structure, Tertiary ras GTPase-Activating Proteins - chemistry ras GTPase-Activating Proteins - genetics ras GTPase-Activating Proteins - metabolism Transcription, Genetic Tumorigenesis vascular endothelial-derived growth factor VEGF
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