Distinct kinetic determinants for the stepwise CCA addition to tRNA

The universally conserved CCA sequence is present at the 3' terminal 74-76 positions of all active tRNA molecules as a functional tag to participate in ribosome protein synthesis. The CCA enzyme catalyzes CCA synthesis in three sequential steps of nucleotide addition at rapid and identical rate...

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Veröffentlicht in:	RNA (Cambridge) 2009-10, Vol.15 (10), p.1827-1836
Hauptverfasser:	Kim, Sangbumn, Liu, Cuiping, Halkidis, Konstantine, Gamper, Howard B, Hou, Ya-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Catalysis Catalytic Domain Kinetics Nucleic Acid Conformation RNA, Transfer - chemistry
Online-Zugang:	Volltext
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