Human Mitochondrial SUV3 and Polynucleotide Phosphorylase Form a 330-kDa Heteropentamer to Cooperatively Degrade Double-stranded RNA with a 3′-to-5′ Directionality

Efficient turnover of unnecessary and misfolded RNAs is critical for maintaining the integrity and function of the mitochondria. The mitochondrial RNA degradosome of budding yeast (mtEXO) has been recently studied and characterized; yet no RNA degradation machinery has been identified in the mammali...

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Veröffentlicht in:	The Journal of biological chemistry 2009-07, Vol.284 (31), p.20812-20821
Hauptverfasser:	Wang, Dennis Ding-Hwa, Shu, Zhanyong, Lieser, Scot A., Chen, Phang-Lang, Lee, Wen-Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Amino Acid Substitution - drug effects DEAD-box RNA Helicases - metabolism Exoribonucleases - metabolism Humans Mitochondria - drug effects Mitochondria - enzymology Models, Biological Molecular Weight Mutant Proteins - metabolism Protein Binding - drug effects Protein Multimerization - drug effects RNA, Double-Stranded - chemistry RNA, Double-Stranded - metabolism RNA: Processing and Catalysis
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