Identification of novel susceptibility loci for Guam neurodegenerative disease: challenges of genome scans in genetic isolates

Amyotrophic lateral sclerosis/parkinsonism–dementia complex (ALS/PDC) is a fatal neurodegenerative disease found in the Chamorro people of Guam and other Pacific Island populations. The etiology is unknown, although both genetic and environmental factors appear important. To identify loci for ALS/PD...

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Veröffentlicht in:	Human molecular genetics 2009-10, Vol.18 (19), p.3725-3738
Hauptverfasser:	Sieh, Weiva, Choi, Yoonha, Chapman, Nicola H., Craig, Ulla-Katrina, Steinbart, Ellen J., Rothstein, Joseph H., Oyanagi, Kiyomitsu, Garruto, Ralph M., Bird, Thomas D., Galasko, Douglas R., Schellenberg, Gerard D., Wijsman, Ellen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Association Studies Biological and medical sciences Case-Control Studies Chromosomes, Human, Pair 12 - genetics Chromosomes, Human, Pair 17 - genetics Female Fundamental and applied biological sciences. Psychology Genetic Linkage Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Guam Humans Male Middle Aged Molecular and cellular biology Native Hawaiian or Other Pacific Islander - genetics Neurodegenerative Diseases - genetics Pedigree Young Adult
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