Transcriptional regulation of the major zinc uptake protein hZip1 in prostate cancer cells

hZip1 has been characterized as the major zinc uptake transporter regulating the accumulation of zinc in prostate cells. The mechanisms regulating expression of hZip1 have not been described. To explore the mechanisms of transcriptional regulation of the hZip1 gene, we determined the putative promot...

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Veröffentlicht in:	Gene 2009-02, Vol.431 (1), p.39-46
Hauptverfasser:	Makhov, Peter, Golovine, Konstantin, Uzzo, Robert G., Wuestefeld, Torsten, Scoll, Benjamin J., Kolenko, Vladimir M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basal transcription Base Sequence Cation Transport Proteins - genetics Cell Line, Tumor Computational Biology Core promoter CREB Cyclic AMP Response Element-Binding Protein - metabolism Gene Expression Regulation, Neoplastic Humans Male Mice Molecular Sequence Data Promoter Regions, Genetic - genetics Prostatic Neoplasms - genetics Protein Binding RNA, Small Interfering - metabolism Sequence Alignment SP1 Sp1 Transcription Factor - metabolism Transcription Initiation Site Transcription, Genetic Transfection Zinc - metabolism
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