Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase

The plant-like, bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) from malaria parasites has been a good target for drug development. Dihydrofolate reductase (DHFR) is inhibited by clinically established antimalarials, pyrimethamine and cycloguanil. Thymidylate synthase (TS) is the...

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Veröffentlicht in:	Molecular and biochemical parasitology 2009-11, Vol.168 (1), p.74-83
Hauptverfasser:	Pang, Cullen K.T., Hunter, Joshua H., Gujjar, Ramesh, Podutoori, Ramulu, Bowman, Julie, Mudeppa, Devaraja G., Rathod, Pradipsinh K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, Affinity Cloning, Molecular Coenzymes - pharmacology Enzyme Enzyme Inhibitors - pharmacology Escherichia coli Escherichia coli - genetics Folic Acid Antagonists - pharmacology Gene Expression Glycine Hydroxymethyltransferase - antagonists & inhibitors Glycine Hydroxymethyltransferase - genetics Glycine Hydroxymethyltransferase - isolation & purification Glycine Hydroxymethyltransferase - metabolism Inhibitor Kinetics Malaria Plasmodium falciparum Plasmodium falciparum - enzymology Protein Binding Pyridoxal Phosphate - pharmacology Recombinant Fusion Proteins - antagonists & inhibitors Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - isolation & purification Recombinant Fusion Proteins - metabolism RNA binding RNA, Messenger - metabolism Serine - metabolism Substrate Specificity Tetrahydrofolates - metabolism
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