Hematopoietic stem cell origin of adipocytes

Objective It has generally been believed that adipocytes are derived from mesenchymal stem cells via fibroblasts. We recently reported that fibroblasts/myofibroblasts in a number of tissues and organs are derived from hematopoietic stem cells (HSCs). In the present study, we tested the hypothesis th...

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Veröffentlicht in:	Experimental hematology 2009-09, Vol.37 (9), p.1108-1120.e4
Hauptverfasser:	Sera, Yasuhiko, LaRue, Amanda C, Moussa, Omar, Mehrotra, Meenal, Duncan, James D, Williams, Christopher R, Nishimoto, Eishi, Schulte, Bradley A, Watson, Patricia M, Watson, Dennis K, Ogawa, Makio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Adipocytes - metabolism Advanced Basic Science Animals Antigens, Differentiation - metabolism Bone Marrow Transplantation Carrier Proteins Cell Differentiation - drug effects Cell Differentiation - physiology Cells, Cultured Diet Fatty Acid-Binding Proteins - biosynthesis Female Hematology, Oncology and Palliative Medicine Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Hypoglycemic Agents - pharmacology Leptin - biosynthesis Male Mice Mice, Transgenic Perilipin-1 Phosphoproteins - biosynthesis PPAR gamma - agonists Thiazolidinediones - pharmacology Transplantation, Homologous
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