Antibacterial activities of a fosfomycin/tobramycin combination: a novel inhaled antibiotic for bronchiectasis

Objectives To compare the in vitro and in vivo activities of a 4:1 (w/w) fosfomycin/tobramycin combination (FTI) with those of fosfomycin and tobramycin alone against cystic fibrosis (CF) and non-CF bronchiectasis pathogens. Methods Clinical isolates of CF Pseudomonas aeruginosa, Staphylococcus aure...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2009-10, Vol.64 (4), p.829-836
Hauptverfasser:	MacLeod, David L., Barker, Lynn M., Sutherland, Jennifer L., Moss, Suzanne C., Gurgel, Jesse L., Kenney, Thomas F., Burns, Jane L., Baker, William R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Bacteria - isolation & purification Bacterial Infections - microbiology Biological and medical sciences Bronchiectasis - complications Burkholderia cepacia Colony Count, Microbial Comparative studies Cystic fibrosis Drug Combinations Drug Interactions Escherichia coli Fosfomycin - administration & dosage Fosfomycin - pharmacology Fosfomycin - therapeutic use Haemophilus influenzae Humans Klebsiella Lung - microbiology Male Medical sciences Microbial Sensitivity Tests Microbial Viability Original Research P. aeruginosa Pharmacology Pharmacology. Drug treatments Pneumology Pneumonia, Bacterial - drug therapy Pseudomonas aeruginosa Rats respiratory infections Respiratory system : syndromes and miscellaneous diseases Respiratory therapy S. aureus Staphylococcus aureus Stenotrophomonas maltophilia Tobramycin - administration & dosage Tobramycin - pharmacology Tobramycin - therapeutic use Treatment Outcome
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