Crystal Structure of Iodotyrosine Deiodinase, a Novel Flavoprotein Responsible for Iodide Salvage in Thyroid Glands

The flavoprotein iodotyrosine deiodinase (IYD) salvages iodide from mono- and diiodotyrosine formed during the biosynthesis of the thyroid hormone thyroxine. Expression of a soluble domain of this membrane-bound enzyme provided sufficient material for crystallization and characterization by x-ray di...

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Veröffentlicht in:	The Journal of biological chemistry 2009-07, Vol.284 (29), p.19659-19667
Hauptverfasser:	Thomas, Seth R., McTamney, Patrick M., Adler, Jennifer M., LaRonde-LeBlanc, Nicole, Rokita, Steven E.
Format:	Artikel
Sprache:	eng
Schlagworte:	08 HYDROGEN Animals AROMATICS Binding Sites BIOSYNTHESIS Carbon - chemistry Cell Line CRYSTAL STRUCTURE CRYSTALLIZATION DIIODOTYROSINE Diiodotyrosine - metabolism DISEASES ELECTRON TRANSFER ENZYMES Flavin Mononucleotide - chemistry Flavin Mononucleotide - metabolism GLANDS HYDROGEN Iodide Peroxidase - chemistry Iodide Peroxidase - genetics Iodide Peroxidase - metabolism IODIDES Iodides - metabolism Iodine - chemistry ISOALLOXAZINES MATERIALS SCIENCE Mice Models, Molecular Mutation MUTATIONS OXIDOREDUCTASES Protein Binding Protein Structure and Folding Protein Structure, Tertiary Spodoptera Substrate Specificity SUBSTRATES THYROID Thyroid Gland - metabolism THYROID HORMONES THYROXINE X-RAY DIFFRACTION
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