Free Thiol Group of MD-2 as the Target for Inhibition of the Lipopolysaccharide-induced Cell Activation

MD-2 is a part of the Toll-like 4 signaling complex with an indispensable role in activation of the lipopolysaccharide (LPS) signaling pathway and thus a suitable target for the therapeutic inhibition of TLR4 signaling. Elucidation of MD-2 structure provides a foundation for rational design of inhib...

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Veröffentlicht in:	The Journal of biological chemistry 2009-07, Vol.284 (29), p.19493-19500
Hauptverfasser:	Manček-Keber, Mateja, Gradišar, Helena, Pestaña, Melania Iñigo, de Tejada, Guillermo Martinez, Jerala, Roman
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Auranofin - chemistry Auranofin - metabolism Auranofin - pharmacology Binding Sites Cell Line Cysteine - chemistry Cysteine - metabolism Dose-Response Relationship, Drug Female Humans Lipopolysaccharides - metabolism Lipopolysaccharides - pharmacology Lymphocyte Antigen 96 - chemistry Lymphocyte Antigen 96 - metabolism Maleimides - chemistry Maleimides - metabolism Maleimides - pharmacology Mechanisms of Signal Transduction Mice Mice, Inbred C57BL Models, Molecular Molecular Structure Protein Binding Protein Structure, Tertiary Pyrenes Signal Transduction - drug effects Sulfhydryl Compounds - chemistry Sulfhydryl Compounds - metabolism Sulfhydryl Compounds - pharmacology Toll-Like Receptors - metabolism Tumor Necrosis Factor-alpha - blood
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