A Genome-wide Short Hairpin RNA Screening of Jurkat T-cells for Human Proteins Contributing to Productive HIV-1 Replication

Short interfering RNAs (siRNAs) have been used to inhibit HIV-1 replication. The durable inhibition of HIV-1 replication by RNA interference has been impeded, however, by a high mutation rate when viral sequences are targeted and by cytotoxicity when cellular genes are knocked down. To identify cell...

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Veröffentlicht in:	The Journal of biological chemistry 2009-07, Vol.284 (29), p.19463-19473
Hauptverfasser:	Yeung, Man Lung, Houzet, Laurent, Yedavalli, Venkat S.R.K., Jeang, Kuan-Teh
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - genetics Antigens, Surface - genetics Cell Line Cell Proliferation DNA-Binding Proteins - genetics Exoribonucleases - genetics Exosome Multienzyme Ribonuclease Complex Flow Cytometry Gene Library Genome, Human Genomics, Proteomics, and Bioinformatics HeLa Cells Histone Acetyltransferases - genetics Histone-Lysine N-Methyltransferase HIV Core Protein p24 - genetics HIV Core Protein p24 - metabolism HIV-1 - genetics HIV-1 - growth & development HIV-1 - metabolism Humans Jurkat Cells Munc18 Proteins - genetics Nuclear Proteins - genetics Nuclear Receptor Coactivator 3 Nuclear Respiratory Factor 1 - genetics Oligonucleotide Array Sequence Analysis - methods Proteins - genetics RNA, Messenger - genetics RNA, Small Interfering - genetics RNA-Binding Proteins Trans-Activators - genetics Transcription Factors - genetics Virus Replication - genetics
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