14-3-3 Protein Masks the DNA Binding Interface of Forkhead Transcription Factor FOXO4

The role of 14-3-3 proteins in the regulation of FOXO forkhead transcription factors is at least 2-fold. First, the 14-3-3 binding inhibits the interaction between the FOXO and the target DNA. Second, the 14-3-3 proteins prevent nuclear reimport of FOXO factors by masking their nuclear localization...

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Veröffentlicht in:	The Journal of biological chemistry 2009-07, Vol.284 (29), p.19349-19360
Hauptverfasser:	Silhan, Jan, Vacha, Petr, Strnadova, Pavla, Vecer, Jaroslav, Herman, Petr, Sulc, Miroslav, Teisinger, Jan, Obsilova, Veronika, Obsil, Tomas
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - chemistry 14-3-3 Proteins - genetics 14-3-3 Proteins - metabolism Binding Sites - genetics Cell Cycle Proteins DNA - chemistry DNA - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Electrophoresis, Polyacrylamide Gel Fluorescence Polarization Forkhead Transcription Factors Humans Models, Molecular Mutation Protein Binding Protein Multimerization Protein Structure and Folding Protein Structure, Tertiary Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism
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