Mecp2 deficiency decreases bone formation and reduces bone volume in a rodent model of Rett syndrome

Abstract Rett syndrome (RTT), a neurological disorder characterized by neurological impairment and a high frequency of osteopenia which often manifests early in childhood, most often is caused by inactivating mutations in the X-linked gene encoding a regulator of epigenetic gene expression, methyl C...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2009-08, Vol.45 (2), p.346-356
Hauptverfasser:	O'Connor, R.D, Zayzafoon, M, Farach-Carson, M.C, Schanen, N.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase Animals Biological and medical sciences Bone and Bones - diagnostic imaging Bone and Bones - pathology Bone formation Cell Count Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Diseases of the osteoarticular system Epigenetics Femur - diagnostic imaging Femur - pathology Fundamental and applied biological sciences. Psychology Growth Plate - pathology Isoenzymes Knockout mouse Male Medical sciences Methyl-CpG-Binding Protein 2 - deficiency Methyl-CpG-Binding Protein 2 - metabolism Mice Neurology Organ Size Orthopedics Osteoblast Osteoclasts - pathology Osteogenesis Osteopenia Osteoporosis. Osteomalacia. Paget disease Osteoprotegerin - metabolism RANK Ligand - metabolism Rett Syndrome - diagnostic imaging Rett Syndrome - pathology Skull - pathology Tartrate-Resistant Acid Phosphatase Vertebrates: anatomy and physiology, studies on body, several organs or systems X-Ray Microtomography
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