Axotomy-Induced Smad1 Activation Promotes Axonal Growth in Adult Sensory Neurons

Mature neurons have diminished intrinsic regenerative capacity. Axotomy of the peripheral branch of adult dorsal root ganglia (a "conditioning" lesion) triggers a transcription-dependent axon growth program. Here, we show that this growth program requires the function of the transcription...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of neuroscience 2009-06, Vol.29 (22), p.7116-7123
Hauptverfasser:	Zou, Hongyan, Ho, Carole, Wong, Karen, Tessier-Lavigne, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Axons - drug effects Axons - physiology Axotomy - methods Bone Morphogenetic Protein 2 - pharmacology Bone Morphogenetic Protein 4 - pharmacology Brief Communications Cells, Cultured Enzyme Activation - drug effects Functional Laterality Ganglia, Spinal - cytology Gene Expression Profiling - methods Gene Expression Regulation - drug effects Mice Microarray Analysis RNA, Small Interfering - pharmacology Sensory Receptor Cells - cytology Sensory Receptor Cells - drug effects Sensory Receptor Cells - physiology Smad1 Protein - genetics Smad1 Protein - metabolism Tubulin - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!