Nonlinear Multisystem Physiological Dysregulation Associated With Frailty in Older Women: Implications for Etiology and Treatment

Background Frailty in older adults, defined as a constellation of signs and symptoms, is associated with abnormal levels in individual physiological systems. We tested the hypothesis that it is the critical mass of physiological systems abnormal that is associated with frailty, over and above the st...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2009-10, Vol.64A (10), p.1049-1057
Hauptverfasser:	Fried, Linda P., Xue, Qian-Li, Cappola, Anne R., Ferrucci, Luigi, Chaves, Paulo, Varadhan, Ravi, Guralnik, Jack M., Leng, Sean X., Semba, Richard D., Walston, Jeremy D., Blaum, Caroline S., Bandeen-Roche, Karen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiposity Aged Aging Cohort Studies Dehydroepiandrosterone Sulfate - blood Female Frail Elderly Frailty Gerontology Health Status Hemoglobins - metabolism Homeostasis - physiology Humans Hypotheses Insulin-Like Growth Factor I - metabolism Interleukin-6 - blood Journal of Gerontology: Medical Sciences Micronutrients - blood Motor Skills - physiology Older people Retrospective Studies Risk Factors Women
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