Inhibition of WNT Signaling by G Protein-Coupled Receptor (GPCR) Kinase 2 (GRK2)

Activation of Wnt signaling pathways causes release and stabilization of the transcription regulator β-catenin from a destruction complex composed of axin and the adenomatous polyposis coli (APC) protein (canonical signaling pathway). Assembly of this complex is facilitated by a protein-protein inte...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2009-09, Vol.23 (9), p.1455-1465
Hauptverfasser:	Wang, Liming, Gesty-Palmer, Diane, Fields, Timothy A, Spurney, Robert F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - metabolism Bone and Bones - metabolism Cell Nucleus - metabolism Culture Media, Conditioned G-Protein-Coupled Receptor Kinase 2 - metabolism Gene Expression Regulation, Enzymologic Humans Mice Models, Biological Protein Interaction Mapping Protein Structure, Tertiary RNA, Small Interfering - metabolism Signal Transduction Wnt Proteins - antagonists & inhibitors
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