Risk of suicide among users of calcium channel blockers: population based, nested case-control study
Estimate of relative risk (95% CI) No (%) of cases (n=38) No (%) of controls (n=140) Crude Adjusted Taking other antihypertensive drugs [dagger] 29 (76) 107 (76) 1.0 1.0 Taking calcium channel blockers 9 (24) 33 (24) 1.01 (0.41 to 2.49) 0.98 (0.30 to 3.18) Body mass index: - - - - =25 13 (34) 64 (46...
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description | Estimate of relative risk (95% CI) No (%) of cases (n=38) No (%) of controls (n=140) Crude Adjusted Taking other antihypertensive drugs [dagger] 29 (76) 107 (76) 1.0 1.0 Taking calcium channel blockers 9 (24) 33 (24) 1.01 (0.41 to 2.49) 0.98 (0.30 to 3.18) Body mass index: - - - - =25 13 (34) 64 (46) 0.50 (0.20 to 1.22) 0.33 (0.11 to 0.98) Unknown 14 (37) 51 (36) 0.60 (0.21 to 1.71) 0.67 (0.17 to 2.63) Smoking status: - - - - Non-smoker or former smoker [dagger] 23 (61) 99 (71) 1.0 1.0 Cigarette smoker 7 (18) 14 (10) 2.10 (0.75 to 5.85) 1.30 (0.31 to 5.36) Unknown 8 (21) 27 (19) 1.40 (0.40 to 4.97) 1.30 (0.23 to 7.33) History of mental illness: - - - - No [dagger] 13 (34) 121 (86) 1.0 1.0 Yes 25 (66) 19 (14) 13.04 (4.89 to 34.80) 15.70 (5.37 to 45.80) * Adjusted for all other covariates simultaneously. [dagger] Reference group. Comment We did not find an increased risk of suicide associated with use of calcium channel blockers compared with use of other antihypertensive drugs. Because of the relatively small number of cases and wide confidence intervals, however, we cannot rule out some effect of the drugs on the risk of suicide. |
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[dagger] Reference group. Comment We did not find an increased risk of suicide associated with use of calcium channel blockers compared with use of other antihypertensive drugs. Because of the relatively small number of cases and wide confidence intervals, however, we cannot rule out some effect of the drugs on the risk of suicide.</description><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>EISSN: 1756-1833</identifier><identifier>DOI: 10.1136/bmj.320.7244.1251</identifier><identifier>PMID: 10797037</identifier><language>eng</language><publisher>England: British Medical Journal Publishing Group</publisher><subject>Adrenergic beta-Antagonists - adverse effects ; Adrenergic beta-Antagonists - therapeutic use ; Antihypertensives ; Body Mass Index ; Calcium ; Calcium channel blockers ; Calcium Channel Blockers - adverse effects ; Calcium Channel Blockers - therapeutic use ; Case control studies ; Cigarette smoking ; Confidence intervals ; Diuretics ; Diuretics - adverse effects ; Diuretics - therapeutic use ; Drug prescriptions ; Drug Therapy, Combination ; Drugs ; General Practice ; Health risk assessment ; Humans ; Hypertension ; Hypertension - drug therapy ; Logistic Models ; Mental disorders ; Mental Disorders - complications ; Mental illness ; Population ecology ; Risk Assessment ; Suicide ; Suicides & suicide attempts</subject><ispartof>BMJ, 2000-05, Vol.320 (7244), p.1251-1251</ispartof><rights>2000 BMJ Publishing Group Ltd.</rights><rights>Copyright 2000 BMJ</rights><rights>Copyright: 2000 (c) 2000 BMJ Publishing Group Ltd.</rights><rights>Copyright © 2000, British Medical Journal 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b450t-4c2f371b0aac2d3d5f398dd35631370e88fa4e202a88c4819e029ee841bc57db3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25224440$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25224440$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10797037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gasse, Christiane</creatorcontrib><creatorcontrib>Derby, Laura E</creatorcontrib><creatorcontrib>Vasilakis, Catherine</creatorcontrib><creatorcontrib>Jick, Hershel</creatorcontrib><title>Risk of suicide among users of calcium channel blockers: population based, nested case-control study</title><title>BMJ</title><addtitle>BMJ</addtitle><description>Estimate of relative risk (95% CI) No (%) of cases (n=38) No (%) of controls (n=140) Crude Adjusted Taking other antihypertensive drugs [dagger] 29 (76) 107 (76) 1.0 1.0 Taking calcium channel blockers 9 (24) 33 (24) 1.01 (0.41 to 2.49) 0.98 (0.30 to 3.18) Body mass index: - - - - <25 [dagger] 11 (29) 25 (18) 1.0 1.0 >=25 13 (34) 64 (46) 0.50 (0.20 to 1.22) 0.33 (0.11 to 0.98) Unknown 14 (37) 51 (36) 0.60 (0.21 to 1.71) 0.67 (0.17 to 2.63) Smoking status: - - - - Non-smoker or former smoker [dagger] 23 (61) 99 (71) 1.0 1.0 Cigarette smoker 7 (18) 14 (10) 2.10 (0.75 to 5.85) 1.30 (0.31 to 5.36) Unknown 8 (21) 27 (19) 1.40 (0.40 to 4.97) 1.30 (0.23 to 7.33) History of mental illness: - - - - No [dagger] 13 (34) 121 (86) 1.0 1.0 Yes 25 (66) 19 (14) 13.04 (4.89 to 34.80) 15.70 (5.37 to 45.80) * Adjusted for all other covariates simultaneously. [dagger] Reference group. Comment We did not find an increased risk of suicide associated with use of calcium channel blockers compared with use of other antihypertensive drugs. Because of the relatively small number of cases and wide confidence intervals, however, we cannot rule out some effect of the drugs on the risk of suicide.</description><subject>Adrenergic beta-Antagonists - adverse effects</subject><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Antihypertensives</subject><subject>Body Mass Index</subject><subject>Calcium</subject><subject>Calcium channel blockers</subject><subject>Calcium Channel Blockers - adverse effects</subject><subject>Calcium Channel Blockers - therapeutic use</subject><subject>Case control studies</subject><subject>Cigarette smoking</subject><subject>Confidence intervals</subject><subject>Diuretics</subject><subject>Diuretics - adverse effects</subject><subject>Diuretics - therapeutic use</subject><subject>Drug prescriptions</subject><subject>Drug Therapy, Combination</subject><subject>Drugs</subject><subject>General Practice</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Logistic Models</subject><subject>Mental disorders</subject><subject>Mental Disorders - complications</subject><subject>Mental illness</subject><subject>Population ecology</subject><subject>Risk Assessment</subject><subject>Suicide</subject><subject>Suicides & suicide 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Laura E</creator><creator>Vasilakis, Catherine</creator><creator>Jick, Hershel</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><general>British Medical 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of suicide among users of calcium channel blockers: population based, nested case-control study</title><author>Gasse, Christiane ; Derby, Laura E ; Vasilakis, Catherine ; Jick, Hershel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b450t-4c2f371b0aac2d3d5f398dd35631370e88fa4e202a88c4819e029ee841bc57db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adrenergic beta-Antagonists - adverse effects</topic><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Antihypertensives</topic><topic>Body Mass Index</topic><topic>Calcium</topic><topic>Calcium channel blockers</topic><topic>Calcium Channel Blockers - adverse effects</topic><topic>Calcium Channel Blockers - therapeutic use</topic><topic>Case control studies</topic><topic>Cigarette smoking</topic><topic>Confidence intervals</topic><topic>Diuretics</topic><topic>Diuretics - adverse effects</topic><topic>Diuretics - therapeutic use</topic><topic>Drug prescriptions</topic><topic>Drug Therapy, Combination</topic><topic>Drugs</topic><topic>General Practice</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - drug therapy</topic><topic>Logistic Models</topic><topic>Mental disorders</topic><topic>Mental Disorders - complications</topic><topic>Mental illness</topic><topic>Population ecology</topic><topic>Risk Assessment</topic><topic>Suicide</topic><topic>Suicides & suicide attempts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gasse, Christiane</creatorcontrib><creatorcontrib>Derby, Laura E</creatorcontrib><creatorcontrib>Vasilakis, Catherine</creatorcontrib><creatorcontrib>Jick, Hershel</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE 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users of calcium channel blockers: population based, nested case-control study</atitle><jtitle>BMJ</jtitle><addtitle>BMJ</addtitle><date>2000-05-06</date><risdate>2000</risdate><volume>320</volume><issue>7244</issue><spage>1251</spage><epage>1251</epage><pages>1251-1251</pages><issn>0959-8138</issn><eissn>1468-5833</eissn><eissn>1756-1833</eissn><abstract>Estimate of relative risk (95% CI) No (%) of cases (n=38) No (%) of controls (n=140) Crude Adjusted Taking other antihypertensive drugs [dagger] 29 (76) 107 (76) 1.0 1.0 Taking calcium channel blockers 9 (24) 33 (24) 1.01 (0.41 to 2.49) 0.98 (0.30 to 3.18) Body mass index: - - - - <25 [dagger] 11 (29) 25 (18) 1.0 1.0 >=25 13 (34) 64 (46) 0.50 (0.20 to 1.22) 0.33 (0.11 to 0.98) Unknown 14 (37) 51 (36) 0.60 (0.21 to 1.71) 0.67 (0.17 to 2.63) Smoking status: - - - - Non-smoker or former smoker [dagger] 23 (61) 99 (71) 1.0 1.0 Cigarette smoker 7 (18) 14 (10) 2.10 (0.75 to 5.85) 1.30 (0.31 to 5.36) Unknown 8 (21) 27 (19) 1.40 (0.40 to 4.97) 1.30 (0.23 to 7.33) History of mental illness: - - - - No [dagger] 13 (34) 121 (86) 1.0 1.0 Yes 25 (66) 19 (14) 13.04 (4.89 to 34.80) 15.70 (5.37 to 45.80) * Adjusted for all other covariates simultaneously. [dagger] Reference group. Comment We did not find an increased risk of suicide associated with use of calcium channel blockers compared with use of other antihypertensive drugs. Because of the relatively small number of cases and wide confidence intervals, however, we cannot rule out some effect of the drugs on the risk of suicide.</abstract><cop>England</cop><pub>British Medical Journal Publishing Group</pub><pmid>10797037</pmid><doi>10.1136/bmj.320.7244.1251</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adrenergic beta-Antagonists - adverse effects Adrenergic beta-Antagonists - therapeutic use Antihypertensives Body Mass Index Calcium Calcium channel blockers Calcium Channel Blockers - adverse effects Calcium Channel Blockers - therapeutic use Case control studies Cigarette smoking Confidence intervals Diuretics Diuretics - adverse effects Diuretics - therapeutic use Drug prescriptions Drug Therapy, Combination Drugs General Practice Health risk assessment Humans Hypertension Hypertension - drug therapy Logistic Models Mental disorders Mental Disorders - complications Mental illness Population ecology Risk Assessment Suicide Suicides & suicide attempts |
title | Risk of suicide among users of calcium channel blockers: population based, nested case-control study |
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