Risk of suicide among users of calcium channel blockers: population based, nested case-control study

Estimate of relative risk (95% CI) No (%) of cases (n=38) No (%) of controls (n=140) Crude Adjusted Taking other antihypertensive drugs [dagger] 29 (76) 107 (76) 1.0 1.0 Taking calcium channel blockers 9 (24) 33 (24) 1.01 (0.41 to 2.49) 0.98 (0.30 to 3.18) Body mass index: - - - - =25 13 (34) 64 (46...

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Veröffentlicht in:BMJ 2000-05, Vol.320 (7244), p.1251-1251
Hauptverfasser: Gasse, Christiane, Derby, Laura E, Vasilakis, Catherine, Jick, Hershel
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container_end_page 1251
container_issue 7244
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container_title BMJ
container_volume 320
creator Gasse, Christiane
Derby, Laura E
Vasilakis, Catherine
Jick, Hershel
description Estimate of relative risk (95% CI) No (%) of cases (n=38) No (%) of controls (n=140) Crude Adjusted Taking other antihypertensive drugs [dagger] 29 (76) 107 (76) 1.0 1.0 Taking calcium channel blockers 9 (24) 33 (24) 1.01 (0.41 to 2.49) 0.98 (0.30 to 3.18) Body mass index: - - - - =25 13 (34) 64 (46) 0.50 (0.20 to 1.22) 0.33 (0.11 to 0.98) Unknown 14 (37) 51 (36) 0.60 (0.21 to 1.71) 0.67 (0.17 to 2.63) Smoking status: - - - - Non-smoker or former smoker [dagger] 23 (61) 99 (71) 1.0 1.0 Cigarette smoker 7 (18) 14 (10) 2.10 (0.75 to 5.85) 1.30 (0.31 to 5.36) Unknown 8 (21) 27 (19) 1.40 (0.40 to 4.97) 1.30 (0.23 to 7.33) History of mental illness: - - - - No [dagger] 13 (34) 121 (86) 1.0 1.0 Yes 25 (66) 19 (14) 13.04 (4.89 to 34.80) 15.70 (5.37 to 45.80) * Adjusted for all other covariates simultaneously. [dagger] Reference group. Comment We did not find an increased risk of suicide associated with use of calcium channel blockers compared with use of other antihypertensive drugs. Because of the relatively small number of cases and wide confidence intervals, however, we cannot rule out some effect of the drugs on the risk of suicide.
doi_str_mv 10.1136/bmj.320.7244.1251
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[dagger] Reference group. Comment We did not find an increased risk of suicide associated with use of calcium channel blockers compared with use of other antihypertensive drugs. Because of the relatively small number of cases and wide confidence intervals, however, we cannot rule out some effect of the drugs on the risk of suicide.</description><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>EISSN: 1756-1833</identifier><identifier>DOI: 10.1136/bmj.320.7244.1251</identifier><identifier>PMID: 10797037</identifier><language>eng</language><publisher>England: British Medical Journal Publishing Group</publisher><subject>Adrenergic beta-Antagonists - adverse effects ; Adrenergic beta-Antagonists - therapeutic use ; Antihypertensives ; Body Mass Index ; Calcium ; Calcium channel blockers ; Calcium Channel Blockers - adverse effects ; Calcium Channel Blockers - therapeutic use ; Case control studies ; Cigarette smoking ; Confidence intervals ; Diuretics ; Diuretics - adverse effects ; Diuretics - therapeutic use ; Drug prescriptions ; Drug Therapy, Combination ; Drugs ; General Practice ; Health risk assessment ; Humans ; Hypertension ; Hypertension - drug therapy ; Logistic Models ; Mental disorders ; Mental Disorders - complications ; Mental illness ; Population ecology ; Risk Assessment ; Suicide ; Suicides &amp; suicide attempts</subject><ispartof>BMJ, 2000-05, Vol.320 (7244), p.1251-1251</ispartof><rights>2000 BMJ Publishing Group Ltd.</rights><rights>Copyright 2000 BMJ</rights><rights>Copyright: 2000 (c) 2000 BMJ Publishing Group Ltd.</rights><rights>Copyright © 2000, British Medical Journal 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b450t-4c2f371b0aac2d3d5f398dd35631370e88fa4e202a88c4819e029ee841bc57db3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25224440$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25224440$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10797037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gasse, Christiane</creatorcontrib><creatorcontrib>Derby, Laura E</creatorcontrib><creatorcontrib>Vasilakis, Catherine</creatorcontrib><creatorcontrib>Jick, Hershel</creatorcontrib><title>Risk of suicide among users of calcium channel blockers: population based, nested case-control study</title><title>BMJ</title><addtitle>BMJ</addtitle><description>Estimate of relative risk (95% CI) No (%) of cases (n=38) No (%) of controls (n=140) Crude Adjusted Taking other antihypertensive drugs [dagger] 29 (76) 107 (76) 1.0 1.0 Taking calcium channel blockers 9 (24) 33 (24) 1.01 (0.41 to 2.49) 0.98 (0.30 to 3.18) Body mass index: - - - - &lt;25 [dagger] 11 (29) 25 (18) 1.0 1.0 &gt;=25 13 (34) 64 (46) 0.50 (0.20 to 1.22) 0.33 (0.11 to 0.98) Unknown 14 (37) 51 (36) 0.60 (0.21 to 1.71) 0.67 (0.17 to 2.63) Smoking status: - - - - Non-smoker or former smoker [dagger] 23 (61) 99 (71) 1.0 1.0 Cigarette smoker 7 (18) 14 (10) 2.10 (0.75 to 5.85) 1.30 (0.31 to 5.36) Unknown 8 (21) 27 (19) 1.40 (0.40 to 4.97) 1.30 (0.23 to 7.33) History of mental illness: - - - - No [dagger] 13 (34) 121 (86) 1.0 1.0 Yes 25 (66) 19 (14) 13.04 (4.89 to 34.80) 15.70 (5.37 to 45.80) * Adjusted for all other covariates simultaneously. [dagger] Reference group. Comment We did not find an increased risk of suicide associated with use of calcium channel blockers compared with use of other antihypertensive drugs. Because of the relatively small number of cases and wide confidence intervals, however, we cannot rule out some effect of the drugs on the risk of suicide.</description><subject>Adrenergic beta-Antagonists - adverse effects</subject><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Antihypertensives</subject><subject>Body Mass Index</subject><subject>Calcium</subject><subject>Calcium channel blockers</subject><subject>Calcium Channel Blockers - adverse effects</subject><subject>Calcium Channel Blockers - therapeutic use</subject><subject>Case control studies</subject><subject>Cigarette smoking</subject><subject>Confidence intervals</subject><subject>Diuretics</subject><subject>Diuretics - adverse effects</subject><subject>Diuretics - therapeutic use</subject><subject>Drug prescriptions</subject><subject>Drug Therapy, Combination</subject><subject>Drugs</subject><subject>General Practice</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Logistic Models</subject><subject>Mental disorders</subject><subject>Mental Disorders - complications</subject><subject>Mental illness</subject><subject>Population ecology</subject><subject>Risk Assessment</subject><subject>Suicide</subject><subject>Suicides &amp; 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[dagger] Reference group. Comment We did not find an increased risk of suicide associated with use of calcium channel blockers compared with use of other antihypertensive drugs. Because of the relatively small number of cases and wide confidence intervals, however, we cannot rule out some effect of the drugs on the risk of suicide.</abstract><cop>England</cop><pub>British Medical Journal Publishing Group</pub><pmid>10797037</pmid><doi>10.1136/bmj.320.7244.1251</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects Adrenergic beta-Antagonists - adverse effects
Adrenergic beta-Antagonists - therapeutic use
Antihypertensives
Body Mass Index
Calcium
Calcium channel blockers
Calcium Channel Blockers - adverse effects
Calcium Channel Blockers - therapeutic use
Case control studies
Cigarette smoking
Confidence intervals
Diuretics
Diuretics - adverse effects
Diuretics - therapeutic use
Drug prescriptions
Drug Therapy, Combination
Drugs
General Practice
Health risk assessment
Humans
Hypertension
Hypertension - drug therapy
Logistic Models
Mental disorders
Mental Disorders - complications
Mental illness
Population ecology
Risk Assessment
Suicide
Suicides & suicide attempts
title Risk of suicide among users of calcium channel blockers: population based, nested case-control study
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