Transitional Versus Surgical Menopause in a Rodent Model: Etiology of Ovarian Hormone Loss Impacts Memory and the Acetylcholine System

Clinical research suggests that type of ovarian hormone loss at menopause influences cognition. Until recently ovariectomy (OVX) has been the primary rodent model to examine effects of ovarian hormone loss on cognition. This model limits evaluations to abrupt and complete ovarian hormone loss, model...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-09, Vol.150 (9), p.4248-4259
Hauptverfasser:	Acosta, Jazmin I, Mayer, Loretta, Talboom, Joshua S, Tsang, Candy Wing S, Smith, Constance J, Enders, Craig K, Bimonte-Nelson, Heather A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Androstenedione Animal models Animals Biological and medical sciences Cholinergic transmission Cholinergics Cognition Cognition & reasoning Cognition - drug effects Cyclohexenes - pharmacology Depletion Female Fundamental and applied biological sciences. Psychology Gonadal Hormones - pharmacology Gonadotropins Hippocampus Hormones Maze Learning - drug effects Memory Memory - drug effects Memory tasks Menopause Menopause - physiology Mental task performance Mnemonics Ovarian Follicle - drug effects Ovariectomy Ovaries Pituitary (anterior) Rats Rodents Scopolamine Spatial Behavior - drug effects Spatial discrimination learning Spatial memory Surgery Vertebrates: endocrinology Vinyl Compounds - pharmacology
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