The Notch Target Gene Hes1 Regulates Cell Cycle Inhibitor Expression in the Developing Pituitary

The pituitary is an endocrine gland responsible for the release of hormones, which regulate growth, metabolism, and reproduction. Diseases such as hypopituitarism or pituitary adenomas are able to disrupt pituitary function leading to suboptimal function of the entire endocrine system. Growth of the...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-09, Vol.150 (9), p.4386-4394
Hauptverfasser:	Monahan, Pamela, Rybak, Sabina, Raetzman, Lori T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - physiology Biological and medical sciences Cell cycle Cell Cycle - genetics Cell death Cell differentiation Cell proliferation Cyclin-dependent kinase Cyclin-dependent kinase inhibitor p27 Cyclin-Dependent Kinase Inhibitor p27 - metabolism Cyclin-Dependent Kinase Inhibitor p57 - metabolism Cyclin-Dependent Kinase Inhibitor Proteins - biosynthesis Cyclin-dependent kinase inhibitors Cyclin-dependent kinases Ectopic expression Embryogenesis Endocrine glands Endocrine system Enhancer-of-split protein Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Homeodomain Proteins - genetics Homeodomain Proteins - physiology Hormones Hypopituitarism Kinases Mice Mutants Pituitary Pituitary Gland - embryology Pituitary Gland - metabolism Progenitor cells Signal transduction Transcription Factor HES-1 Vertebrates: endocrinology
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