Brain-Derived Neurotrophic Factor in Infants <32 Weeks Gestational Age: Correlation With Antenatal Factors and Postnatal Outcomes
Neurotrophins (NTs) play important roles in brain growth and development. Cord blood (CB) brain-derived neurotrophic factor (BDNF) concentrations increase with gestational age but data regarding postnatal changes are limited. We measured BDNF concentrations after birth in 33 preterm infants
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| Veröffentlicht in: | Pediatric research 2009-05, Vol.65 (5), p.548-552 |
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| creator | Rao, Rakesh Mashburn, Charles B Mao, Jingnan Wadhwa, Nitin Smith, George M Desai, Nirmala S |
| description | Neurotrophins (NTs) play important roles in brain growth and development. Cord blood (CB) brain-derived neurotrophic factor (BDNF) concentrations increase with gestational age but data regarding postnatal changes are limited. We measured BDNF concentrations after birth in 33 preterm infants |
| doi_str_mv | 10.1203/PDR.0b013e31819d9ea5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2735819</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67510213</sourcerecordid><originalsourceid>FETCH-LOGICAL-c482t-87d7742ccc086aa19eff614ac3095e703149882fff22c6e978fe6424136647b53</originalsourceid><addsrcrecordid>eNp9kU1vEzEQhi0EomnhHyDkC9y2-Gt3bYSQQkpLpYpWCNSj5TjjxGVjB9tbqUf-OYaNyseBk6V5n3k9My9Czyg5pozwV1cnn47JklAOnEqqVgpM-wDNaMtJQ4ToH6IZIZw2XCl5gA5zviGEilaKx-iAKqpIy9UMfX-XjA_NCSR_Cyv8EcYUS4q7jbf41NgSE_YBnwdnQsn4DWf4GuBrxmeQiyk-BjPg-Rpe40VMCYZfJXztywbPQ4FgStUnn4xNWOGrmMtUvRyLjVvIT9AjZ4YMT_fvEfpy-v7z4kNzcXl2vphfNFZIVhrZr_peMGstkZ0xVIFzHRXGcqJa6OumQknJnHOM2Q5ULx10ggnKu070y5YfobeT725cbmFlIZRkBr1LfmvSnY7G67-V4Dd6HW8163lbD1wNXu4NUvw21v311mcLw2ACxDHrrm8pYZRXUEygTTHnBO7-E0r0z-x0zU7_m11te_7ngL-b9mFV4MUeMNmawSUTrM_3HKOCcC5F5dqJy1UKa0j6Jo6pJpX_P8AP9Ia2Iw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67510213</pqid></control><display><type>article</type><title>Brain-Derived Neurotrophic Factor in Infants <32 Weeks Gestational Age: Correlation With Antenatal Factors and Postnatal Outcomes</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Rao, Rakesh ; Mashburn, Charles B ; Mao, Jingnan ; Wadhwa, Nitin ; Smith, George M ; Desai, Nirmala S</creator><creatorcontrib>Rao, Rakesh ; Mashburn, Charles B ; Mao, Jingnan ; Wadhwa, Nitin ; Smith, George M ; Desai, Nirmala S</creatorcontrib><description>Neurotrophins (NTs) play important roles in brain growth and development. Cord blood (CB) brain-derived neurotrophic factor (BDNF) concentrations increase with gestational age but data regarding postnatal changes are limited. We measured BDNF concentrations after birth in 33 preterm infants <32-wk gestation. Serum was collected at birth (CB), at day 2, between day 6 and 10 (D6), at day 30 (D30), and at day 60 (D60). BDNF concentrations fell on D2 (
p
= 0.03), recovered by D6 (
p
= 0.10), and continued to rise thereafter at D30 (
p
= 0.06) and D60 (
p
= 0.01) compared with CB. CB BDNF concentrations positively correlated with duration of rupture of membranes (
r
= 0.43,
p
= 0.04). Antenatal steroids (ANS,
p
= 0.02), postnatal steroids (PNS,
p
= 0.04), and retinopathy of prematurity (ROP,
p
= 0.02) were identified as significant factors in multivariate analyses. The median (25–75th interquartile range) CB BDNF concentrations were higher in infants who received a complete course ANS compared with those who received a partial course [1461 (553–2064)
versus
281 (171–536) pg/mL,
p
= 0.04]. BDNF concentrations
negatively
correlated with the use of PNS at D30 (
r
= −0.53,
p
= 0.002) and at D60 (
r
= −0.55,
p
= 0.009). PNS use was associated with reduced concentrations of BDNF at D30 [733 (101–1983)
versus
2224 (1677–4400) pg/mL,
p
= 0.004] and at D60 [1149 (288–2270)
versus
2560 (1337–5166) pg/mL,
p
= 0.01]. BDNF concentrations on D60 in infants who developed ROP (
n
= 16) were lower than those who did not develop ROP (
n
= 7) [1417 (553–2540)
versus
3593 (2620–7433) pg/mL, respectively,
p
= 0.005]. Our data suggests that BDNF concentrations rise beyond the first week of age. BDNF concentrations correlate with factors that influence neurodevelopment outcomes.</description><identifier>ISSN: 0031-3998</identifier><identifier>ISSN: 1530-0447</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1203/PDR.0b013e31819d9ea5</identifier><identifier>PMID: 19190539</identifier><identifier>CODEN: PEREBL</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Age Factors ; Biological and medical sciences ; Birth Weight ; Brain - drug effects ; Brain - growth & development ; Brain - metabolism ; Brain-Derived Neurotrophic Factor - blood ; Bronchopulmonary Dysplasia - blood ; Cerebral Hemorrhage - blood ; Child Development ; clinical-investigation ; Drug Administration Schedule ; Enterocolitis, Necrotizing - blood ; Female ; Fetal Blood - metabolism ; Fetal Membranes, Premature Rupture - blood ; General aspects ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Multivariate Analysis ; Pediatric Surgery ; Pediatrics ; Pregnancy ; Prospective Studies ; Retinopathy of Prematurity - blood ; Steroids - administration & dosage</subject><ispartof>Pediatric research, 2009-05, Vol.65 (5), p.548-552</ispartof><rights>International Pediatrics Research Foundation, Inc. 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-87d7742ccc086aa19eff614ac3095e703149882fff22c6e978fe6424136647b53</citedby><cites>FETCH-LOGICAL-c482t-87d7742ccc086aa19eff614ac3095e703149882fff22c6e978fe6424136647b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21403384$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19190539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rao, Rakesh</creatorcontrib><creatorcontrib>Mashburn, Charles B</creatorcontrib><creatorcontrib>Mao, Jingnan</creatorcontrib><creatorcontrib>Wadhwa, Nitin</creatorcontrib><creatorcontrib>Smith, George M</creatorcontrib><creatorcontrib>Desai, Nirmala S</creatorcontrib><title>Brain-Derived Neurotrophic Factor in Infants <32 Weeks Gestational Age: Correlation With Antenatal Factors and Postnatal Outcomes</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Neurotrophins (NTs) play important roles in brain growth and development. Cord blood (CB) brain-derived neurotrophic factor (BDNF) concentrations increase with gestational age but data regarding postnatal changes are limited. We measured BDNF concentrations after birth in 33 preterm infants <32-wk gestation. Serum was collected at birth (CB), at day 2, between day 6 and 10 (D6), at day 30 (D30), and at day 60 (D60). BDNF concentrations fell on D2 (
p
= 0.03), recovered by D6 (
p
= 0.10), and continued to rise thereafter at D30 (
p
= 0.06) and D60 (
p
= 0.01) compared with CB. CB BDNF concentrations positively correlated with duration of rupture of membranes (
r
= 0.43,
p
= 0.04). Antenatal steroids (ANS,
p
= 0.02), postnatal steroids (PNS,
p
= 0.04), and retinopathy of prematurity (ROP,
p
= 0.02) were identified as significant factors in multivariate analyses. The median (25–75th interquartile range) CB BDNF concentrations were higher in infants who received a complete course ANS compared with those who received a partial course [1461 (553–2064)
versus
281 (171–536) pg/mL,
p
= 0.04]. BDNF concentrations
negatively
correlated with the use of PNS at D30 (
r
= −0.53,
p
= 0.002) and at D60 (
r
= −0.55,
p
= 0.009). PNS use was associated with reduced concentrations of BDNF at D30 [733 (101–1983)
versus
2224 (1677–4400) pg/mL,
p
= 0.004] and at D60 [1149 (288–2270)
versus
2560 (1337–5166) pg/mL,
p
= 0.01]. BDNF concentrations on D60 in infants who developed ROP (
n
= 16) were lower than those who did not develop ROP (
n
= 7) [1417 (553–2540)
versus
3593 (2620–7433) pg/mL, respectively,
p
= 0.005]. Our data suggests that BDNF concentrations rise beyond the first week of age. BDNF concentrations correlate with factors that influence neurodevelopment outcomes.</description><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>Brain - drug effects</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Bronchopulmonary Dysplasia - blood</subject><subject>Cerebral Hemorrhage - blood</subject><subject>Child Development</subject><subject>clinical-investigation</subject><subject>Drug Administration Schedule</subject><subject>Enterocolitis, Necrotizing - blood</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Fetal Membranes, Premature Rupture - blood</subject><subject>General aspects</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multivariate Analysis</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Retinopathy of Prematurity - blood</subject><subject>Steroids - administration & dosage</subject><issn>0031-3998</issn><issn>1530-0447</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1vEzEQhi0EomnhHyDkC9y2-Gt3bYSQQkpLpYpWCNSj5TjjxGVjB9tbqUf-OYaNyseBk6V5n3k9My9Czyg5pozwV1cnn47JklAOnEqqVgpM-wDNaMtJQ4ToH6IZIZw2XCl5gA5zviGEilaKx-iAKqpIy9UMfX-XjA_NCSR_Cyv8EcYUS4q7jbf41NgSE_YBnwdnQsn4DWf4GuBrxmeQiyk-BjPg-Rpe40VMCYZfJXztywbPQ4FgStUnn4xNWOGrmMtUvRyLjVvIT9AjZ4YMT_fvEfpy-v7z4kNzcXl2vphfNFZIVhrZr_peMGstkZ0xVIFzHRXGcqJa6OumQknJnHOM2Q5ULx10ggnKu070y5YfobeT725cbmFlIZRkBr1LfmvSnY7G67-V4Dd6HW8163lbD1wNXu4NUvw21v311mcLw2ACxDHrrm8pYZRXUEygTTHnBO7-E0r0z-x0zU7_m11te_7ngL-b9mFV4MUeMNmawSUTrM_3HKOCcC5F5dqJy1UKa0j6Jo6pJpX_P8AP9Ia2Iw</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Rao, Rakesh</creator><creator>Mashburn, Charles B</creator><creator>Mao, Jingnan</creator><creator>Wadhwa, Nitin</creator><creator>Smith, George M</creator><creator>Desai, Nirmala S</creator><general>Nature Publishing Group US</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090501</creationdate><title>Brain-Derived Neurotrophic Factor in Infants <32 Weeks Gestational Age: Correlation With Antenatal Factors and Postnatal Outcomes</title><author>Rao, Rakesh ; Mashburn, Charles B ; Mao, Jingnan ; Wadhwa, Nitin ; Smith, George M ; Desai, Nirmala S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-87d7742ccc086aa19eff614ac3095e703149882fff22c6e978fe6424136647b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>Brain - drug effects</topic><topic>Brain - growth & development</topic><topic>Brain - metabolism</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>Bronchopulmonary Dysplasia - blood</topic><topic>Cerebral Hemorrhage - blood</topic><topic>Child Development</topic><topic>clinical-investigation</topic><topic>Drug Administration Schedule</topic><topic>Enterocolitis, Necrotizing - blood</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Fetal Membranes, Premature Rupture - blood</topic><topic>General aspects</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multivariate Analysis</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Retinopathy of Prematurity - blood</topic><topic>Steroids - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rao, Rakesh</creatorcontrib><creatorcontrib>Mashburn, Charles B</creatorcontrib><creatorcontrib>Mao, Jingnan</creatorcontrib><creatorcontrib>Wadhwa, Nitin</creatorcontrib><creatorcontrib>Smith, George M</creatorcontrib><creatorcontrib>Desai, Nirmala S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rao, Rakesh</au><au>Mashburn, Charles B</au><au>Mao, Jingnan</au><au>Wadhwa, Nitin</au><au>Smith, George M</au><au>Desai, Nirmala S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain-Derived Neurotrophic Factor in Infants <32 Weeks Gestational Age: Correlation With Antenatal Factors and Postnatal Outcomes</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>65</volume><issue>5</issue><spage>548</spage><epage>552</epage><pages>548-552</pages><issn>0031-3998</issn><issn>1530-0447</issn><eissn>1530-0447</eissn><coden>PEREBL</coden><abstract>Neurotrophins (NTs) play important roles in brain growth and development. Cord blood (CB) brain-derived neurotrophic factor (BDNF) concentrations increase with gestational age but data regarding postnatal changes are limited. We measured BDNF concentrations after birth in 33 preterm infants <32-wk gestation. Serum was collected at birth (CB), at day 2, between day 6 and 10 (D6), at day 30 (D30), and at day 60 (D60). BDNF concentrations fell on D2 (
p
= 0.03), recovered by D6 (
p
= 0.10), and continued to rise thereafter at D30 (
p
= 0.06) and D60 (
p
= 0.01) compared with CB. CB BDNF concentrations positively correlated with duration of rupture of membranes (
r
= 0.43,
p
= 0.04). Antenatal steroids (ANS,
p
= 0.02), postnatal steroids (PNS,
p
= 0.04), and retinopathy of prematurity (ROP,
p
= 0.02) were identified as significant factors in multivariate analyses. The median (25–75th interquartile range) CB BDNF concentrations were higher in infants who received a complete course ANS compared with those who received a partial course [1461 (553–2064)
versus
281 (171–536) pg/mL,
p
= 0.04]. BDNF concentrations
negatively
correlated with the use of PNS at D30 (
r
= −0.53,
p
= 0.002) and at D60 (
r
= −0.55,
p
= 0.009). PNS use was associated with reduced concentrations of BDNF at D30 [733 (101–1983)
versus
2224 (1677–4400) pg/mL,
p
= 0.004] and at D60 [1149 (288–2270)
versus
2560 (1337–5166) pg/mL,
p
= 0.01]. BDNF concentrations on D60 in infants who developed ROP (
n
= 16) were lower than those who did not develop ROP (
n
= 7) [1417 (553–2540)
versus
3593 (2620–7433) pg/mL, respectively,
p
= 0.005]. Our data suggests that BDNF concentrations rise beyond the first week of age. BDNF concentrations correlate with factors that influence neurodevelopment outcomes.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>19190539</pmid><doi>10.1203/PDR.0b013e31819d9ea5</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Age Factors Biological and medical sciences Birth Weight Brain - drug effects Brain - growth & development Brain - metabolism Brain-Derived Neurotrophic Factor - blood Bronchopulmonary Dysplasia - blood Cerebral Hemorrhage - blood Child Development clinical-investigation Drug Administration Schedule Enterocolitis, Necrotizing - blood Female Fetal Blood - metabolism Fetal Membranes, Premature Rupture - blood General aspects Gestational Age Humans Infant, Newborn Infant, Premature Male Medical sciences Medicine Medicine & Public Health Multivariate Analysis Pediatric Surgery Pediatrics Pregnancy Prospective Studies Retinopathy of Prematurity - blood Steroids - administration & dosage |
| title | Brain-Derived Neurotrophic Factor in Infants <32 Weeks Gestational Age: Correlation With Antenatal Factors and Postnatal Outcomes |
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