Polycyclic aromatic hydrocarbon–DNA adducts and survival among women with breast cancer
Polycyclic aromatic hydrocarbons (PAH) are mammary carcinogens in animal studies, and a few epidemiologic studies have suggested a link between elevated levels of PAH–DNA adducts and breast cancer incidence. An association between PAH–DNA adducts and survival among breast cancer cases has not been p...
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| Veröffentlicht in: | Environmental research 2009-04, Vol.109 (3), p.287-291 |
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| creator | Sagiv, Sharon K. Gaudet, Mia M. Eng, Sybil M. Abrahamson, Page E. Shantakumar, Sumitra Teitelbaum, Susan L. Bell, Paula Thomas, Joyce A. Neugut, Alfred I. Santella, Regina M. Gammon, Marilie D. |
| description | Polycyclic aromatic hydrocarbons (PAH) are mammary carcinogens in animal studies, and a few epidemiologic studies have suggested a link between elevated levels of PAH–DNA adducts and breast cancer incidence. An association between PAH–DNA adducts and survival among breast cancer cases has not been previously reported. We conducted a survival analysis among women with newly diagnosed invasive breast cancer between 1996 and 1997, enrolled in the Long Island Breast Cancer Study Project. DNA was isolated from blood samples that were obtained from cases shortly after diagnosis and assayed for PAH–DNA adducts using ELISA. Among the 722 cases with PAH–DNA adduct measurements, 97 deaths (13.4%) from all causes and 54 deaths (7.5%) due to breast cancer were reported to the National Death Index (NDI) by December 31, 2002. Using Cox proportional hazards models and controlling for age at diagnosis, we did not find evidence that all-cause mortality (hazard ratio (HR)=0.88; 95% confidence interval (CI): 0.57–1.37), or breast cancer mortality (HR=1.20; 95% CI: 0.63–2.28) was strongly associated with detectable PAH–DNA adduct levels compared with non-detectable adducts; additionally, no dose–response association was observed. Among a subgroup with treatment data (
n=520), adducts were associated with over a two-fold higher mortality among those receiving radiation, but mortality for adducts was reduced among hormone therapy users. Results from this large population-based study do not provide strong support for an association between detectable PAH–DNA adducts and survival among women with breast cancer, except perhaps among those receiving radiation treatment. |
| doi_str_mv | 10.1016/j.envres.2008.11.005 |
| format | Article |
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n=520), adducts were associated with over a two-fold higher mortality among those receiving radiation, but mortality for adducts was reduced among hormone therapy users. Results from this large population-based study do not provide strong support for an association between detectable PAH–DNA adducts and survival among women with breast cancer, except perhaps among those receiving radiation treatment.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/j.envres.2008.11.005</identifier><identifier>PMID: 19181313</identifier><identifier>CODEN: ENVRAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>60 APPLIED LIFE SCIENCES ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; BLOOD ; Breast neoplasms ; Breast Neoplasms - blood ; Breast Neoplasms - mortality ; Carcinogenesis, carcinogens and anticarcinogens ; CARCINOGENS ; Carcinogens, Environmental - toxicity ; Case-Control Studies ; Chemical agents ; DEATH ; DIAGNOSIS ; DNA ; DNA ADDUCTS ; DNA Adducts - blood ; Environment. Living conditions ; Environmental health ; ENZYME IMMUNOASSAY ; ESTROGENS ; Female ; Gynecology. Andrology. Obstetrics ; HEALTH HAZARDS ; Humans ; Incidence ; Mammary gland diseases ; MAMMARY GLANDS ; Medical sciences ; Middle Aged ; MORTALITY ; NEOPLASMS ; Outcome Assessment (Health Care) ; POLYCYCLIC AROMATIC HYDROCARBONS ; Polycyclic Aromatic Hydrocarbons - blood ; Polycyclic Aromatic Hydrocarbons - toxicity ; Predictive Value of Tests ; PROGESTERONE ; Proportional Hazards Models ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; RECEPTORS ; Survival Analysis ; Tumors ; WOMEN ; Young Adult</subject><ispartof>Environmental research, 2009-04, Vol.109 (3), p.287-291</ispartof><rights>2008 Elsevier Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-dfd475ad97602e391d63e7193b5f5941a715e6c96dbf4be8b15bb67bf520af3e3</citedby><cites>FETCH-LOGICAL-c550t-dfd475ad97602e391d63e7193b5f5941a715e6c96dbf4be8b15bb67bf520af3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.envres.2008.11.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21304039$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19181313$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/21176124$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Sagiv, Sharon K.</creatorcontrib><creatorcontrib>Gaudet, Mia M.</creatorcontrib><creatorcontrib>Eng, Sybil M.</creatorcontrib><creatorcontrib>Abrahamson, Page E.</creatorcontrib><creatorcontrib>Shantakumar, Sumitra</creatorcontrib><creatorcontrib>Teitelbaum, Susan L.</creatorcontrib><creatorcontrib>Bell, Paula</creatorcontrib><creatorcontrib>Thomas, Joyce A.</creatorcontrib><creatorcontrib>Neugut, Alfred I.</creatorcontrib><creatorcontrib>Santella, Regina M.</creatorcontrib><creatorcontrib>Gammon, Marilie D.</creatorcontrib><title>Polycyclic aromatic hydrocarbon–DNA adducts and survival among women with breast cancer</title><title>Environmental research</title><addtitle>Environ Res</addtitle><description>Polycyclic aromatic hydrocarbons (PAH) are mammary carcinogens in animal studies, and a few epidemiologic studies have suggested a link between elevated levels of PAH–DNA adducts and breast cancer incidence. An association between PAH–DNA adducts and survival among breast cancer cases has not been previously reported. We conducted a survival analysis among women with newly diagnosed invasive breast cancer between 1996 and 1997, enrolled in the Long Island Breast Cancer Study Project. DNA was isolated from blood samples that were obtained from cases shortly after diagnosis and assayed for PAH–DNA adducts using ELISA. Among the 722 cases with PAH–DNA adduct measurements, 97 deaths (13.4%) from all causes and 54 deaths (7.5%) due to breast cancer were reported to the National Death Index (NDI) by December 31, 2002. Using Cox proportional hazards models and controlling for age at diagnosis, we did not find evidence that all-cause mortality (hazard ratio (HR)=0.88; 95% confidence interval (CI): 0.57–1.37), or breast cancer mortality (HR=1.20; 95% CI: 0.63–2.28) was strongly associated with detectable PAH–DNA adduct levels compared with non-detectable adducts; additionally, no dose–response association was observed. Among a subgroup with treatment data (
n=520), adducts were associated with over a two-fold higher mortality among those receiving radiation, but mortality for adducts was reduced among hormone therapy users. Results from this large population-based study do not provide strong support for an association between detectable PAH–DNA adducts and survival among women with breast cancer, except perhaps among those receiving radiation treatment.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>BLOOD</subject><subject>Breast neoplasms</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - mortality</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>CARCINOGENS</subject><subject>Carcinogens, Environmental - toxicity</subject><subject>Case-Control Studies</subject><subject>Chemical agents</subject><subject>DEATH</subject><subject>DIAGNOSIS</subject><subject>DNA</subject><subject>DNA ADDUCTS</subject><subject>DNA Adducts - blood</subject><subject>Environment. Living conditions</subject><subject>Environmental health</subject><subject>ENZYME IMMUNOASSAY</subject><subject>ESTROGENS</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>HEALTH HAZARDS</subject><subject>Humans</subject><subject>Incidence</subject><subject>Mammary gland diseases</subject><subject>MAMMARY GLANDS</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MORTALITY</subject><subject>NEOPLASMS</subject><subject>Outcome Assessment (Health Care)</subject><subject>POLYCYCLIC AROMATIC HYDROCARBONS</subject><subject>Polycyclic Aromatic Hydrocarbons - blood</subject><subject>Polycyclic Aromatic Hydrocarbons - toxicity</subject><subject>Predictive Value of Tests</subject><subject>PROGESTERONE</subject><subject>Proportional Hazards Models</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>RECEPTORS</subject><subject>Survival Analysis</subject><subject>Tumors</subject><subject>WOMEN</subject><subject>Young Adult</subject><issn>0013-9351</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EotPCGyAUCcEuwdeOnckGqSq_UgUsYMHKcuybjkeJXewk1ex4h74hT4JHM2phw8q2_N2fcw4hz4BWQEG-3lbol4ipYpSuK4CKUvGArIC2sqSt4A_JilLgZcsFnJDTlLb5CYLTx-QEWlgDB74iP76GYWd2ZnCm0DGMesqXzc7GYHTsgv_96_bt5_NCWzubKRXa2yLNcXGLHgo9Bn9V3IQRfXHjpk3RRdRpKoz2BuMT8qjXQ8Knx_OMfH__7tvFx_Lyy4dPF-eXpRGCTqXtbd0IbdtGUoa8BSs5NtDyTvSirUE3IFCaVtqurztcdyC6TjZdLxjVPUd-Rt4c-l7P3YjWoJ-iHtR1dKOOOxW0U__-eLdRV2FRrMnOgMwNXhwahDQ5lYyb0GxM8B7NpBhAI4HVmXp1HBPDzxnTpEaXDA6D9hjmpBitGQMJGawPoIkhpYj93SpA1T45tVWH5NQ-OQWgcnK57PnfMu6LjlFl4OUR0MnooY_ZZZfuOAac1pS3935gNn1xGPeSMCdiXdwrssH9f5M_lxO7oA</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Sagiv, Sharon K.</creator><creator>Gaudet, Mia M.</creator><creator>Eng, Sybil M.</creator><creator>Abrahamson, Page E.</creator><creator>Shantakumar, Sumitra</creator><creator>Teitelbaum, Susan L.</creator><creator>Bell, Paula</creator><creator>Thomas, Joyce A.</creator><creator>Neugut, Alfred I.</creator><creator>Santella, Regina M.</creator><creator>Gammon, Marilie D.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TV</scope><scope>7U7</scope><scope>C1K</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>20090401</creationdate><title>Polycyclic aromatic hydrocarbon–DNA adducts and survival among women with breast cancer</title><author>Sagiv, Sharon K. ; Gaudet, Mia M. ; Eng, Sybil M. ; Abrahamson, Page E. ; Shantakumar, Sumitra ; Teitelbaum, Susan L. ; Bell, Paula ; Thomas, Joyce A. ; Neugut, Alfred I. ; Santella, Regina M. ; Gammon, Marilie D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-dfd475ad97602e391d63e7193b5f5941a715e6c96dbf4be8b15bb67bf520af3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>BLOOD</topic><topic>Breast neoplasms</topic><topic>Breast Neoplasms - blood</topic><topic>Breast Neoplasms - mortality</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>CARCINOGENS</topic><topic>Carcinogens, Environmental - toxicity</topic><topic>Case-Control Studies</topic><topic>Chemical agents</topic><topic>DEATH</topic><topic>DIAGNOSIS</topic><topic>DNA</topic><topic>DNA ADDUCTS</topic><topic>DNA Adducts - blood</topic><topic>Environment. Living conditions</topic><topic>Environmental health</topic><topic>ENZYME IMMUNOASSAY</topic><topic>ESTROGENS</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>HEALTH HAZARDS</topic><topic>Humans</topic><topic>Incidence</topic><topic>Mammary gland diseases</topic><topic>MAMMARY GLANDS</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MORTALITY</topic><topic>NEOPLASMS</topic><topic>Outcome Assessment (Health Care)</topic><topic>POLYCYCLIC AROMATIC HYDROCARBONS</topic><topic>Polycyclic Aromatic Hydrocarbons - blood</topic><topic>Polycyclic Aromatic Hydrocarbons - toxicity</topic><topic>Predictive Value of Tests</topic><topic>PROGESTERONE</topic><topic>Proportional Hazards Models</topic><topic>Public health. Hygiene</topic><topic>Public health. 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An association between PAH–DNA adducts and survival among breast cancer cases has not been previously reported. We conducted a survival analysis among women with newly diagnosed invasive breast cancer between 1996 and 1997, enrolled in the Long Island Breast Cancer Study Project. DNA was isolated from blood samples that were obtained from cases shortly after diagnosis and assayed for PAH–DNA adducts using ELISA. Among the 722 cases with PAH–DNA adduct measurements, 97 deaths (13.4%) from all causes and 54 deaths (7.5%) due to breast cancer were reported to the National Death Index (NDI) by December 31, 2002. Using Cox proportional hazards models and controlling for age at diagnosis, we did not find evidence that all-cause mortality (hazard ratio (HR)=0.88; 95% confidence interval (CI): 0.57–1.37), or breast cancer mortality (HR=1.20; 95% CI: 0.63–2.28) was strongly associated with detectable PAH–DNA adduct levels compared with non-detectable adducts; additionally, no dose–response association was observed. Among a subgroup with treatment data (
n=520), adducts were associated with over a two-fold higher mortality among those receiving radiation, but mortality for adducts was reduced among hormone therapy users. Results from this large population-based study do not provide strong support for an association between detectable PAH–DNA adducts and survival among women with breast cancer, except perhaps among those receiving radiation treatment.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>19181313</pmid><doi>10.1016/j.envres.2008.11.005</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Environmental research, 2009-04, Vol.109 (3), p.287-291 |
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| subjects | 60 APPLIED LIFE SCIENCES Adult Aged Aged, 80 and over Biological and medical sciences BLOOD Breast neoplasms Breast Neoplasms - blood Breast Neoplasms - mortality Carcinogenesis, carcinogens and anticarcinogens CARCINOGENS Carcinogens, Environmental - toxicity Case-Control Studies Chemical agents DEATH DIAGNOSIS DNA DNA ADDUCTS DNA Adducts - blood Environment. Living conditions Environmental health ENZYME IMMUNOASSAY ESTROGENS Female Gynecology. Andrology. Obstetrics HEALTH HAZARDS Humans Incidence Mammary gland diseases MAMMARY GLANDS Medical sciences Middle Aged MORTALITY NEOPLASMS Outcome Assessment (Health Care) POLYCYCLIC AROMATIC HYDROCARBONS Polycyclic Aromatic Hydrocarbons - blood Polycyclic Aromatic Hydrocarbons - toxicity Predictive Value of Tests PROGESTERONE Proportional Hazards Models Public health. Hygiene Public health. Hygiene-occupational medicine RECEPTORS Survival Analysis Tumors WOMEN Young Adult |
| title | Polycyclic aromatic hydrocarbon–DNA adducts and survival among women with breast cancer |
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