Structural Similarity Enhances Interaction Propensity of Proteins

We study statistical properties of interacting protein-like surfaces and predict two strong, related effects: (i) statistically enhanced self-attraction of proteins; (ii) statistically enhanced attraction of proteins with similar structures. The effects originate in the fact that the probability to...

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Veröffentlicht in:	Journal of molecular biology 2007-02, Vol.365 (5), p.1596-1606
Hauptverfasser:	Lukatsky, D.B., Shakhnovich, B.E., Mintseris, J., Shakhnovich, E.I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids Bacterial Proteins Databases, Protein Dimerization DNA-Binding Proteins Evolution, Molecular homodimers and heterodimers Models, Molecular positive and negative design principles of biomolecular recognition Protein Binding protein networks Proteins - chemistry Proteins - metabolism protein–protein interactions Structural Homology, Protein Structure-Activity Relationship
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