Phosphorylation of ΔFosB mediates its stability in vivo

Abstract The transcription factor, ΔFosB, accumulates in a region-specific manner in brain in response to many types of chronic stimulation due to the unusual stability of the protein. The phosphorylation of Ser27 in ΔFosB has been shown to promote this stability in vitro. We show here that this pho...

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Veröffentlicht in:	Neuroscience 2009-01, Vol.158 (2), p.369-372
Hauptverfasser:	Ulery-Reynolds, P.G, Castillo, M.A, Vialou, V, Russo, S.J, Nestler, E.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences casein kinase 2 cocaine Fundamental and applied biological sciences. Psychology Medical sciences Neurology Neuropharmacology nucleus accumbens Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Vertebrates: nervous system and sense organs viral gene transfer
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Zusammenfassung:	Abstract The transcription factor, ΔFosB, accumulates in a region-specific manner in brain in response to many types of chronic stimulation due to the unusual stability of the protein. The phosphorylation of Ser27 in ΔFosB has been shown to promote this stability in vitro. We show here that this phosphorylation reaction is also important for ΔFosB's stability in the brain in vivo and for the unique behavioral plasticity mediated by this transcription factor.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2008.10.059