PDF Cells Are a GABA-Responsive Wake-Promoting Component of the Drosophila Sleep Circuit

Daily sleep cycles in humans are driven by a complex circuit within which GABAergic sleep-promoting neurons oppose arousal. Drosophila sleep has recently been shown to be controlled by GABA, which acts on unknown cells expressing the Rdl GABAA receptor. We identify here the relevant Rdl-containing c...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2008-11, Vol.60 (4), p.672-682
Hauptverfasser:	Parisky, Katherine M., Agosto, Jose, Pulver, Stefan R., Shang, Yuhua, Kuklin, Elena, Hodge, James J.L., Kang, Keongjin, Liu, Xu, Garrity, Paul A., Rosbash, Michael, Griffith, Leslie C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arousal - physiology Biological Evolution Brain Brain - cytology Brain - metabolism CELLBIO Circadian rhythm Circadian Rhythm - physiology Drosophila melanogaster - physiology Drosophila Proteins - genetics Drosophila Proteins - metabolism gamma-Aminobutyric Acid - metabolism Grants Insects Mammals Mammals - physiology Molecular Biology - methods MOLNEURO Neural Pathways - cytology Neural Pathways - metabolism Neurons Neurons - cytology Neurons - metabolism Neuropeptides - metabolism Peptides Proteins Rodents Sleep - physiology Software Species Specificity Synaptic Transmission - physiology SYSNEURO TRPA1 Cation Channel TRPC Cation Channels - genetics TRPC Cation Channels - metabolism Wakefulness - physiology
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