Subcellular localization of Nox4 and regulation in diabetes

Oxidative stress is implicated in human diseases. Some of the oxidative pathways are harbored in the mitochondria. NAD(P)H oxidases have been identified not only in phagocytic but also in somatic cells. Nox4 is the most ubiquitous of these oxidases and is a major source of reactive oxygen species (R...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-08, Vol.106 (34), p.14385-14390
Hauptverfasser:	Block, Karen, Gorin, Yves, Abboud, Hanna E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biological Sciences Blotting, Western Cells Cells, Cultured Diabetes Diabetes complications Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - metabolism Diabetic nephropathies Endothelial cells Enzymes Gene expression Gene Expression Regulation Immunoprecipitation Kidney cortex Kidney Cortex - cytology Kidney Cortex - metabolism Kidneys Male Mesangial Cells - cytology Mesangial Cells - metabolism Microscopy, Confocal Mitochondria Mitochondria - metabolism NADPH Oxidase 4 NADPH Oxidases - genetics NADPH Oxidases - metabolism Nephrons Oxidases Oxidation Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics Superoxides Tissues Transfection
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