Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging
Convergent evidence implicates white matter abnormalities in bipolar disorder. The cingulum is an important candidate structure for study in bipolar disorder as it provides substantial white matter connections within the corticolimbic neural system that subserves emotional regulation involved in the...
Gespeichert in:
| Veröffentlicht in: | British journal of psychiatry 2008-08, Vol.193 (2), p.126-129 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 129 |
|---|---|
| container_issue | 2 |
| container_start_page | 126 |
| container_title | British journal of psychiatry |
| container_volume | 193 |
| creator | Wang, Fei Jackowski, Marcel Kalmar, Jessica H. Chepenik, Lara G. Tie, Karen Qiu, Maolin Gong, Gaolang Pittman, Brian P. Jones, Monique M. Shah, Maulik P. Spencer, Linda Papademetris, Xenophon Constable, R. Todd Blumberg, Hilary P. |
| description | Convergent evidence implicates white matter abnormalities in bipolar disorder. The cingulum is an important candidate structure for study in bipolar disorder as it provides substantial white matter connections within the corticolimbic neural system that subserves emotional regulation involved in the disorder.
To test the hypothesis that bipolar disorder is associated with abnormal white matter integrity in the cingulum.
Fractional anisotropy in the anterior and posterior cingulum was compared between 42 participants with bipolar disorder and 42 healthy participants using diffusion tensor imaging.
Fractional anisotropy was significantly decreased in the anterior cingulum in the bipolar disorder group compared with the healthy group (P=0.003); however, fractional anisotropy in the posterior cingulum did not differ significantly between groups.
Our findings demonstrate abnormalities in the structural integrity of the anterior cingulum in bipolar disorder. They extend evidence that supports involvement of the neural system comprising the anterior cingulate cortex and its corticolimbic gray matter connection sites in bipolar disorder to implicate abnormalities in the white matter connections within the system provided by the cingulum. |
| doi_str_mv | 10.1192/bjp.bp.107.048793 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2732002</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1192_bjp_bp_107_048793</cupid><sourcerecordid>2315602586</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-b57f91272b5a4ca5a39251f2998b8decef96b0977f7d552831d8af65bdcd576c3</originalsourceid><addsrcrecordid>eNqFkV2L1TAQhoso7nH1B3gjFcG7HpNJkzQ3wrLsqrDgjV6HfLXNoU1q0irn35vlHFwVxKvMZJ55Z5K3ql5itMdYwDt9WPZ62WPE96jtuCCPqh1uOTS4ZfRxtUMI8QYDRRfVs5wPJSUt8KfVBe4YE0KwXWWvdIhpVlOtwuqSj6k2PgzbtM21LzdD8uuxRLX2S5xUqq3PMVlXAlf42Qdn63VMcRvGUuv7LfsY6tWFgtV-VkNRe1496dWU3YvzeVl9vb35cv2xufv84dP11V1jKLC10ZT3AgMHTVVrFFVEAMU9CNHpzjrjesE0Epz33FIKHcG2Uz2j2hpLOTPksnp_0l02PTtrXFiTmuSSyh7pKKPy8s9K8KMc4ncJnABCUATengVS_La5vMrZZ-OmSQUXtyyZIBwE6v4LUg4UkMAFfPMXeIhbCuUXJBBMGQLasULhE2VSzDm5_tfOGMl7q2WxWuqlpFyerC49r35_7EPH2dsCvD4Box_GHz45mcySj2aUWBAJEsM9Q86D1ayTt4N72O_fo38CGDbE5A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2315602586</pqid></control><display><type>article</type><title>Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Cambridge Journals Online</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Wang, Fei ; Jackowski, Marcel ; Kalmar, Jessica H. ; Chepenik, Lara G. ; Tie, Karen ; Qiu, Maolin ; Gong, Gaolang ; Pittman, Brian P. ; Jones, Monique M. ; Shah, Maulik P. ; Spencer, Linda ; Papademetris, Xenophon ; Constable, R. Todd ; Blumberg, Hilary P.</creator><creatorcontrib>Wang, Fei ; Jackowski, Marcel ; Kalmar, Jessica H. ; Chepenik, Lara G. ; Tie, Karen ; Qiu, Maolin ; Gong, Gaolang ; Pittman, Brian P. ; Jones, Monique M. ; Shah, Maulik P. ; Spencer, Linda ; Papademetris, Xenophon ; Constable, R. Todd ; Blumberg, Hilary P.</creatorcontrib><description>Convergent evidence implicates white matter abnormalities in bipolar disorder. The cingulum is an important candidate structure for study in bipolar disorder as it provides substantial white matter connections within the corticolimbic neural system that subserves emotional regulation involved in the disorder.
To test the hypothesis that bipolar disorder is associated with abnormal white matter integrity in the cingulum.
Fractional anisotropy in the anterior and posterior cingulum was compared between 42 participants with bipolar disorder and 42 healthy participants using diffusion tensor imaging.
Fractional anisotropy was significantly decreased in the anterior cingulum in the bipolar disorder group compared with the healthy group (P=0.003); however, fractional anisotropy in the posterior cingulum did not differ significantly between groups.
Our findings demonstrate abnormalities in the structural integrity of the anterior cingulum in bipolar disorder. They extend evidence that supports involvement of the neural system comprising the anterior cingulate cortex and its corticolimbic gray matter connection sites in bipolar disorder to implicate abnormalities in the white matter connections within the system provided by the cingulum.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.bp.107.048793</identifier><identifier>PMID: 18669996</identifier><identifier>CODEN: BJPYAJ</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Age ; Anisotropy ; Attention deficit hyperactivity disorder ; Bipolar affective disorder ; Bipolar disorder ; Bipolar Disorder - pathology ; Bipolar Disorder - physiopathology ; Brain imaging ; Brain Mapping - methods ; Candidates ; Case-Control Studies ; Cingulum ; Cortex ; Cortex (cingulate) ; Diffusion Magnetic Resonance Imaging - methods ; Diffusion tensor imaging ; Emotional regulation ; Female ; Gyrus Cinguli - pathology ; Gyrus Cinguli - physiopathology ; Humans ; Magnetic resonance imaging ; Male ; Models, Neurological ; Morality ; Nervous system ; Neuroimaging ; NMR ; Nuclear magnetic resonance ; Psychiatry ; Statistics as Topic ; Substantia alba ; Substantia grisea</subject><ispartof>British journal of psychiatry, 2008-08, Vol.193 (2), p.126-129</ispartof><rights>Copyright © Royal College of Psychiatrists, 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-b57f91272b5a4ca5a39251f2998b8decef96b0977f7d552831d8af65bdcd576c3</citedby><cites>FETCH-LOGICAL-c526t-b57f91272b5a4ca5a39251f2998b8decef96b0977f7d552831d8af65bdcd576c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007125000235514/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,230,314,776,780,881,12825,27901,27902,30976,30977,55603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18669996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Fei</creatorcontrib><creatorcontrib>Jackowski, Marcel</creatorcontrib><creatorcontrib>Kalmar, Jessica H.</creatorcontrib><creatorcontrib>Chepenik, Lara G.</creatorcontrib><creatorcontrib>Tie, Karen</creatorcontrib><creatorcontrib>Qiu, Maolin</creatorcontrib><creatorcontrib>Gong, Gaolang</creatorcontrib><creatorcontrib>Pittman, Brian P.</creatorcontrib><creatorcontrib>Jones, Monique M.</creatorcontrib><creatorcontrib>Shah, Maulik P.</creatorcontrib><creatorcontrib>Spencer, Linda</creatorcontrib><creatorcontrib>Papademetris, Xenophon</creatorcontrib><creatorcontrib>Constable, R. Todd</creatorcontrib><creatorcontrib>Blumberg, Hilary P.</creatorcontrib><title>Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging</title><title>British journal of psychiatry</title><addtitle>Br J Psychiatry</addtitle><description>Convergent evidence implicates white matter abnormalities in bipolar disorder. The cingulum is an important candidate structure for study in bipolar disorder as it provides substantial white matter connections within the corticolimbic neural system that subserves emotional regulation involved in the disorder.
To test the hypothesis that bipolar disorder is associated with abnormal white matter integrity in the cingulum.
Fractional anisotropy in the anterior and posterior cingulum was compared between 42 participants with bipolar disorder and 42 healthy participants using diffusion tensor imaging.
Fractional anisotropy was significantly decreased in the anterior cingulum in the bipolar disorder group compared with the healthy group (P=0.003); however, fractional anisotropy in the posterior cingulum did not differ significantly between groups.
Our findings demonstrate abnormalities in the structural integrity of the anterior cingulum in bipolar disorder. They extend evidence that supports involvement of the neural system comprising the anterior cingulate cortex and its corticolimbic gray matter connection sites in bipolar disorder to implicate abnormalities in the white matter connections within the system provided by the cingulum.</description><subject>Adult</subject><subject>Age</subject><subject>Anisotropy</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Bipolar affective disorder</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - pathology</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Brain imaging</subject><subject>Brain Mapping - methods</subject><subject>Candidates</subject><subject>Case-Control Studies</subject><subject>Cingulum</subject><subject>Cortex</subject><subject>Cortex (cingulate)</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Diffusion tensor imaging</subject><subject>Emotional regulation</subject><subject>Female</subject><subject>Gyrus Cinguli - pathology</subject><subject>Gyrus Cinguli - physiopathology</subject><subject>Humans</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Models, Neurological</subject><subject>Morality</subject><subject>Nervous system</subject><subject>Neuroimaging</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Psychiatry</subject><subject>Statistics as Topic</subject><subject>Substantia alba</subject><subject>Substantia grisea</subject><issn>0007-1250</issn><issn>1472-1465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkV2L1TAQhoso7nH1B3gjFcG7HpNJkzQ3wrLsqrDgjV6HfLXNoU1q0irn35vlHFwVxKvMZJ55Z5K3ql5itMdYwDt9WPZ62WPE96jtuCCPqh1uOTS4ZfRxtUMI8QYDRRfVs5wPJSUt8KfVBe4YE0KwXWWvdIhpVlOtwuqSj6k2PgzbtM21LzdD8uuxRLX2S5xUqq3PMVlXAlf42Qdn63VMcRvGUuv7LfsY6tWFgtV-VkNRe1496dWU3YvzeVl9vb35cv2xufv84dP11V1jKLC10ZT3AgMHTVVrFFVEAMU9CNHpzjrjesE0Epz33FIKHcG2Uz2j2hpLOTPksnp_0l02PTtrXFiTmuSSyh7pKKPy8s9K8KMc4ncJnABCUATengVS_La5vMrZZ-OmSQUXtyyZIBwE6v4LUg4UkMAFfPMXeIhbCuUXJBBMGQLasULhE2VSzDm5_tfOGMl7q2WxWuqlpFyerC49r35_7EPH2dsCvD4Box_GHz45mcySj2aUWBAJEsM9Q86D1ayTt4N72O_fo38CGDbE5A</recordid><startdate>200808</startdate><enddate>200808</enddate><creator>Wang, Fei</creator><creator>Jackowski, Marcel</creator><creator>Kalmar, Jessica H.</creator><creator>Chepenik, Lara G.</creator><creator>Tie, Karen</creator><creator>Qiu, Maolin</creator><creator>Gong, Gaolang</creator><creator>Pittman, Brian P.</creator><creator>Jones, Monique M.</creator><creator>Shah, Maulik P.</creator><creator>Spencer, Linda</creator><creator>Papademetris, Xenophon</creator><creator>Constable, R. Todd</creator><creator>Blumberg, Hilary P.</creator><general>Cambridge University Press</general><general>RCP</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7TK</scope><scope>7XB</scope><scope>88G</scope><scope>88J</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>M2M</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200808</creationdate><title>Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging</title><author>Wang, Fei ; Jackowski, Marcel ; Kalmar, Jessica H. ; Chepenik, Lara G. ; Tie, Karen ; Qiu, Maolin ; Gong, Gaolang ; Pittman, Brian P. ; Jones, Monique M. ; Shah, Maulik P. ; Spencer, Linda ; Papademetris, Xenophon ; Constable, R. Todd ; Blumberg, Hilary P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-b57f91272b5a4ca5a39251f2998b8decef96b0977f7d552831d8af65bdcd576c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Age</topic><topic>Anisotropy</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Bipolar affective disorder</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - pathology</topic><topic>Bipolar Disorder - physiopathology</topic><topic>Brain imaging</topic><topic>Brain Mapping - methods</topic><topic>Candidates</topic><topic>Case-Control Studies</topic><topic>Cingulum</topic><topic>Cortex</topic><topic>Cortex (cingulate)</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Diffusion tensor imaging</topic><topic>Emotional regulation</topic><topic>Female</topic><topic>Gyrus Cinguli - pathology</topic><topic>Gyrus Cinguli - physiopathology</topic><topic>Humans</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Models, Neurological</topic><topic>Morality</topic><topic>Nervous system</topic><topic>Neuroimaging</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Psychiatry</topic><topic>Statistics as Topic</topic><topic>Substantia alba</topic><topic>Substantia grisea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Fei</creatorcontrib><creatorcontrib>Jackowski, Marcel</creatorcontrib><creatorcontrib>Kalmar, Jessica H.</creatorcontrib><creatorcontrib>Chepenik, Lara G.</creatorcontrib><creatorcontrib>Tie, Karen</creatorcontrib><creatorcontrib>Qiu, Maolin</creatorcontrib><creatorcontrib>Gong, Gaolang</creatorcontrib><creatorcontrib>Pittman, Brian P.</creatorcontrib><creatorcontrib>Jones, Monique M.</creatorcontrib><creatorcontrib>Shah, Maulik P.</creatorcontrib><creatorcontrib>Spencer, Linda</creatorcontrib><creatorcontrib>Papademetris, Xenophon</creatorcontrib><creatorcontrib>Constable, R. Todd</creatorcontrib><creatorcontrib>Blumberg, Hilary P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>ProQuest Psychology</collection><collection>ProQuest Research Library</collection><collection>Social Science Journals (ProQuest)</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Fei</au><au>Jackowski, Marcel</au><au>Kalmar, Jessica H.</au><au>Chepenik, Lara G.</au><au>Tie, Karen</au><au>Qiu, Maolin</au><au>Gong, Gaolang</au><au>Pittman, Brian P.</au><au>Jones, Monique M.</au><au>Shah, Maulik P.</au><au>Spencer, Linda</au><au>Papademetris, Xenophon</au><au>Constable, R. Todd</au><au>Blumberg, Hilary P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging</atitle><jtitle>British journal of psychiatry</jtitle><addtitle>Br J Psychiatry</addtitle><date>2008-08</date><risdate>2008</risdate><volume>193</volume><issue>2</issue><spage>126</spage><epage>129</epage><pages>126-129</pages><issn>0007-1250</issn><eissn>1472-1465</eissn><coden>BJPYAJ</coden><abstract>Convergent evidence implicates white matter abnormalities in bipolar disorder. The cingulum is an important candidate structure for study in bipolar disorder as it provides substantial white matter connections within the corticolimbic neural system that subserves emotional regulation involved in the disorder.
To test the hypothesis that bipolar disorder is associated with abnormal white matter integrity in the cingulum.
Fractional anisotropy in the anterior and posterior cingulum was compared between 42 participants with bipolar disorder and 42 healthy participants using diffusion tensor imaging.
Fractional anisotropy was significantly decreased in the anterior cingulum in the bipolar disorder group compared with the healthy group (P=0.003); however, fractional anisotropy in the posterior cingulum did not differ significantly between groups.
Our findings demonstrate abnormalities in the structural integrity of the anterior cingulum in bipolar disorder. They extend evidence that supports involvement of the neural system comprising the anterior cingulate cortex and its corticolimbic gray matter connection sites in bipolar disorder to implicate abnormalities in the white matter connections within the system provided by the cingulum.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>18669996</pmid><doi>10.1192/bjp.bp.107.048793</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1250 |
| ispartof | British journal of psychiatry, 2008-08, Vol.193 (2), p.126-129 |
| issn | 0007-1250 1472-1465 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2732002 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); Cambridge Journals Online; MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adult Age Anisotropy Attention deficit hyperactivity disorder Bipolar affective disorder Bipolar disorder Bipolar Disorder - pathology Bipolar Disorder - physiopathology Brain imaging Brain Mapping - methods Candidates Case-Control Studies Cingulum Cortex Cortex (cingulate) Diffusion Magnetic Resonance Imaging - methods Diffusion tensor imaging Emotional regulation Female Gyrus Cinguli - pathology Gyrus Cinguli - physiopathology Humans Magnetic resonance imaging Male Models, Neurological Morality Nervous system Neuroimaging NMR Nuclear magnetic resonance Psychiatry Statistics as Topic Substantia alba Substantia grisea |
| title | Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T17%3A28%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Abnormal%20anterior%20cingulum%20integrity%20in%20bipolar%20disorder%20determined%20through%20diffusion%20tensor%20imaging&rft.jtitle=British%20journal%20of%20psychiatry&rft.au=Wang,%20Fei&rft.date=2008-08&rft.volume=193&rft.issue=2&rft.spage=126&rft.epage=129&rft.pages=126-129&rft.issn=0007-1250&rft.eissn=1472-1465&rft.coden=BJPYAJ&rft_id=info:doi/10.1192/bjp.bp.107.048793&rft_dat=%3Cproquest_pubme%3E2315602586%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2315602586&rft_id=info:pmid/18669996&rft_cupid=10_1192_bjp_bp_107_048793&rfr_iscdi=true |