Impaired Estrogen Feedback and Infertility in Female Mice with Pituitary-Specific Deletion of Estrogen Receptor Alpha (ESR1)

Mice lacking estrogen receptor alpha in the pituitary gonadotroph (PitEsr1KO) were generated to determine the physiologic role of pituitary estrogen signaling in the reproductive axis. PitEsr1KO female mice are subfertile or infertile and have elevated levels of serum luteinizing hormone (LH) and LH...

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Veröffentlicht in:	Biology of reproduction 2009-09, Vol.81 (3), p.488-496
Hauptverfasser:	Singh, Surya P, Wolfe, Andrew, Ng, Yewade, DiVall, Sara A, Buggs, Colleen, Levine, Jon E, Wondisford, Fredric E, Radovick, Sally
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism Estrogens - blood Estrogens - metabolism Estrogens - pharmacology Estrous Cycle - blood Estrous Cycle - genetics Feedback, Physiological - drug effects Feedback, Physiological - physiology Female Gonadal Steroid Hormones - blood Infertility, Female - blood Infertility, Female - genetics Infertility, Female - metabolism Infertility, Female - pathology Luteinizing Hormone - blood Mice Mice, Inbred C57BL Mice, Knockout Neuroendocrinology Organ Specificity - genetics Ovary - metabolism Ovary - pathology Pituitary Gland - metabolism
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