Mislabeled units of umbilical cord blood detected by a quality assurance program at the transplantation center
We instituted procedures to check the identity of cord blood unit provided for transplantation by carrying out ABO and human leukocyte antigen (HLA) typing of the thawed units before transplantation. ABO typing is done using standard techniques. Rapid HLA class I serology is with monoclonal antibody...
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| Veröffentlicht in: | Blood 2009-08, Vol.114 (8), p.1684-1688 |
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| creator | McCullough, Jeffrey McKenna, David Kadidlo, Diane Maurer, David Noreen, Harriett J. French, Kathy Brunstein, Claudio Wagner, John E. |
| description | We instituted procedures to check the identity of cord blood unit provided for transplantation by carrying out ABO and human leukocyte antigen (HLA) typing of the thawed units before transplantation. ABO typing is done using standard techniques. Rapid HLA class I serology is with monoclonal antibody trays (One Lambda Inc) using standard incubations. One mislabeled umbilical cord blood (UCB) unit was detected on the day of intended transplantation by repeat ABO typing of the thawed unit at our transplantation center. Because ABO typing will not detect all labeling errors, the rapid serologic class I HLA typing procedure was done on thawed units just before transplantation for all units without an attached segment. This procedure identified a second mislabeled unit. In a 6-year period, 2 of 871 (0.2%) cord blood units sent to us for transplantation were mislabeled and potentially would have been transplanted incorrectly. This error rate of 1 per 249 (0.4%) patients could have potentially devastating consequences. |
| doi_str_mv | 10.1182/blood-2009-02-205047 |
| format | Article |
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ABO typing is done using standard techniques. Rapid HLA class I serology is with monoclonal antibody trays (One Lambda Inc) using standard incubations. One mislabeled umbilical cord blood (UCB) unit was detected on the day of intended transplantation by repeat ABO typing of the thawed unit at our transplantation center. Because ABO typing will not detect all labeling errors, the rapid serologic class I HLA typing procedure was done on thawed units just before transplantation for all units without an attached segment. This procedure identified a second mislabeled unit. In a 6-year period, 2 of 871 (0.2%) cord blood units sent to us for transplantation were mislabeled and potentially would have been transplanted incorrectly. 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This error rate of 1 per 249 (0.4%) patients could have potentially devastating consequences.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Blood Banking - methods</subject><subject>Blood Banks - organization & administration</subject><subject>Blood Banks - standards</subject><subject>Blood Grouping and Crossmatching</subject><subject>Blood Transfusion - standards</subject><subject>Efficiency, Organizational</subject><subject>Female</subject><subject>Fetal Blood - transplantation</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Male</subject><subject>Medical Errors - prevention & control</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Product Labeling - standards</subject><subject>Quality Control</subject><subject>Transfusion Medicine</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1TAQhiMEoofCGyDkDewC41ucbJBQVWilIjawthxn3Bo58antVOrb4_QctbBhNb7888_la5q3FD5S2rNPY4hxahnA0AKrUYJQz5odlaxvARg8b3YA0LViUPSkeZXzbwAqOJMvmxM6iF4xqXbN8t3nYEYMOJF18SWT6Mg6jz54awKxMU3koRKZsKAtVTbeE0NuVxN8qaec12QWi2Sf4nUyMzGFlBskpb7mfTBLMcXHhVhcCqbXzQtnQsY3x3ja_Pp6_vPsor368e3y7MtVa6VUpeXILDfUCKfASioBZNePvOthcH1negFMWOYQB-6mTjHgbputXjl3THF-2nw--O7XccZpK55M0PvkZ5PudTRe__uz-Bt9He90Taad2Aw-HA1SvF0xFz37bDHUgTCuWXdKDpIKWYXiILQp5pzQPRahoDdQ-mF9egOlgekDqJr27u8Gn5KOZKrg_VFgciXhtiX7_KhjtOdCdfA0KdZ13nlMOluPFcjkU-Wlp-j_38kfslSzsg</recordid><startdate>20090820</startdate><enddate>20090820</enddate><creator>McCullough, Jeffrey</creator><creator>McKenna, David</creator><creator>Kadidlo, Diane</creator><creator>Maurer, David</creator><creator>Noreen, Harriett J.</creator><creator>French, Kathy</creator><creator>Brunstein, Claudio</creator><creator>Wagner, John E.</creator><general>Elsevier Inc</general><general>Americain Society of Hematology</general><general>American Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090820</creationdate><title>Mislabeled units of umbilical cord blood detected by a quality assurance program at the transplantation center</title><author>McCullough, Jeffrey ; 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Biological and medical sciences Blood Banking - methods Blood Banks - organization & administration Blood Banks - standards Blood Grouping and Crossmatching Blood Transfusion - standards Efficiency, Organizational Female Fetal Blood - transplantation Hematologic and hematopoietic diseases Humans Male Medical Errors - prevention & control Medical sciences Middle Aged Product Labeling - standards Quality Control Transfusion Medicine |
| title | Mislabeled units of umbilical cord blood detected by a quality assurance program at the transplantation center |
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