Activation of the Fibrinolytic Cascade Early in Pregnancy Among Women With Spontaneous Preterm Birth
To evaluate the association of early pregnancy concentrations of thrombin-antithrombin III complex with subsequent spontaneous preterm birth. In a nested case-control study, thrombin-antithrombin III complex was measured in plasma before 20 weeks of gestation (mean 9.9 weeks) among women without chr...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 2008-11, Vol.112 (5), p.1116-1122 |
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| creator | Catov, J M. Bodnar, L M. Hackney, D Roberts, J M. Simhan, H N. |
| description | To evaluate the association of early pregnancy concentrations of thrombin-antithrombin III complex with subsequent spontaneous preterm birth.
In a nested case-control study, thrombin-antithrombin III complex was measured in plasma before 20 weeks of gestation (mean 9.9 weeks) among women without chronic conditions, preeclampsia, or growth restriction. C-reactive protein and non-high-density lipoprotein cholesterol were also measured. Women with spontaneous preterm birth before 34 weeks of gestation (n=29) and 34 weeks to 36 weeks of gestation (n=72) were compared with women with term births occurring at or after 37 weeks (n=219). Polychotomous logistic regression was used to relate elevated thrombin-antithrombin III complex (greater than 5.5 ng/mL), dyslipidemia (non-high-density lipoprotein cholesterol greater than the 90th percentile), and inflammation (C-reactive protein at or above 8 micrograms/mL) to risk of spontaneous preterm birth subtypes.
Women with spontaneous preterm birth compared with term births had elevated thrombin-antithrombin III complex (P=.02), and they were more likely to have a thrombin-antithrombin III complex greater than 5.5 ng/mL (P |
| doi_str_mv | 10.1097/AOG.0b013e31818aa5b5 |
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In a nested case-control study, thrombin-antithrombin III complex was measured in plasma before 20 weeks of gestation (mean 9.9 weeks) among women without chronic conditions, preeclampsia, or growth restriction. C-reactive protein and non-high-density lipoprotein cholesterol were also measured. Women with spontaneous preterm birth before 34 weeks of gestation (n=29) and 34 weeks to 36 weeks of gestation (n=72) were compared with women with term births occurring at or after 37 weeks (n=219). Polychotomous logistic regression was used to relate elevated thrombin-antithrombin III complex (greater than 5.5 ng/mL), dyslipidemia (non-high-density lipoprotein cholesterol greater than the 90th percentile), and inflammation (C-reactive protein at or above 8 micrograms/mL) to risk of spontaneous preterm birth subtypes.
Women with spontaneous preterm birth compared with term births had elevated thrombin-antithrombin III complex (P=.02), and they were more likely to have a thrombin-antithrombin III complex greater than 5.5 ng/mL (P<.01). Women with thrombin-antithrombin III complex in the highest compared with lowest quartile had a 4.6-fold (95% confidence interval 1.3-15.8) increased risk for spontaneous preterm birth before 34 weeks of gestation, adjusted for body mass index, race, inflammation, dyslipidemia, and gestational age at sampling. There was a dose-response trend between thrombin-antithrombin III complex and spontaneous preterm birth before 34 weeks (P<.01) and 34 to 36 weeks (P=.03).
There is evidence of early pregnancy systemic fibrinolysis among women with spontaneous preterm birth before 34 weeks of gestation independent of inflammation and dyslipidemia, perhaps secondary to microvascular injury.
II.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1097/AOG.0b013e31818aa5b5</identifier><identifier>PMID: 18978114</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: The American College of Obstetricians and Gynecologists</publisher><subject>Adolescent ; Adult ; Antithrombin III ; Biological and medical sciences ; C-Reactive Protein - analysis ; Case-Control Studies ; Diseases of mother, fetus and pregnancy ; Female ; Fibrinolysis ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Odds Ratio ; Peptide Hydrolases - blood ; Pregnancy ; Pregnancy Trimester, Second - blood ; Pregnancy. Fetus. Placenta ; Premature Birth - blood ; Young Adult</subject><ispartof>Obstetrics and gynecology (New York. 1953), 2008-11, Vol.112 (5), p.1116-1122</ispartof><rights>The American College of Obstetricians and Gynecologists</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4812-5ceb685c9a6895ed819f1b8b3f68844f90f8cd5b6d0deff25a350e03a1b4f6753</citedby><cites>FETCH-LOGICAL-c4812-5ceb685c9a6895ed819f1b8b3f68844f90f8cd5b6d0deff25a350e03a1b4f6753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20825089$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18978114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Catov, J M.</creatorcontrib><creatorcontrib>Bodnar, L M.</creatorcontrib><creatorcontrib>Hackney, D</creatorcontrib><creatorcontrib>Roberts, J M.</creatorcontrib><creatorcontrib>Simhan, H N.</creatorcontrib><title>Activation of the Fibrinolytic Cascade Early in Pregnancy Among Women With Spontaneous Preterm Birth</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>To evaluate the association of early pregnancy concentrations of thrombin-antithrombin III complex with subsequent spontaneous preterm birth.
In a nested case-control study, thrombin-antithrombin III complex was measured in plasma before 20 weeks of gestation (mean 9.9 weeks) among women without chronic conditions, preeclampsia, or growth restriction. C-reactive protein and non-high-density lipoprotein cholesterol were also measured. Women with spontaneous preterm birth before 34 weeks of gestation (n=29) and 34 weeks to 36 weeks of gestation (n=72) were compared with women with term births occurring at or after 37 weeks (n=219). Polychotomous logistic regression was used to relate elevated thrombin-antithrombin III complex (greater than 5.5 ng/mL), dyslipidemia (non-high-density lipoprotein cholesterol greater than the 90th percentile), and inflammation (C-reactive protein at or above 8 micrograms/mL) to risk of spontaneous preterm birth subtypes.
Women with spontaneous preterm birth compared with term births had elevated thrombin-antithrombin III complex (P=.02), and they were more likely to have a thrombin-antithrombin III complex greater than 5.5 ng/mL (P<.01). Women with thrombin-antithrombin III complex in the highest compared with lowest quartile had a 4.6-fold (95% confidence interval 1.3-15.8) increased risk for spontaneous preterm birth before 34 weeks of gestation, adjusted for body mass index, race, inflammation, dyslipidemia, and gestational age at sampling. There was a dose-response trend between thrombin-antithrombin III complex and spontaneous preterm birth before 34 weeks (P<.01) and 34 to 36 weeks (P=.03).
There is evidence of early pregnancy systemic fibrinolysis among women with spontaneous preterm birth before 34 weeks of gestation independent of inflammation and dyslipidemia, perhaps secondary to microvascular injury.
II.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antithrombin III</subject><subject>Biological and medical sciences</subject><subject>C-Reactive Protein - analysis</subject><subject>Case-Control Studies</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Fibrinolysis</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Odds Ratio</subject><subject>Peptide Hydrolases - blood</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second - blood</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Premature Birth - blood</subject><subject>Young Adult</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV9vFCEUxYnR2HX1GxjDi75N5c8wAy8m66atJk1qoqa-EYaBHZSBFdg2--1ls5tWfSCE8Lvn3nsOAK8xOsdI9O9XN1fnaECYGoo55kqxgT0BC8x72hBKfzwFC4SIaHretmfgRc4_EUK4E_Q5OMNc9BzjdgHGlS7uThUXA4wWlsnASzckF6LfF6fhWmWtRgMvVPJ76AL8kswmqKD3cDXHsIG3cTYB3roywa_bGIoKJu7yASsmzfCjS2V6CZ5Z5bN5dbqX4Pvlxbf1p-b65urzenXd6JZj0jBtho4zLVTHBTMjx8LigQ_UdrwuYQWyXI9s6EY0GmsJU5Qhg6jCQ2u7ntEl-HDU3e6G2YzahJKUl9vkZpX2Mion__0JbpKbeCdJT3Hbiyrw7iSQ4u-dyUXOLmvj_XEr2YmeobZ6vgTtEdQp5pyMfWiCkTzEI2s88v94atmbvwd8LDrlUYG3J-Dgu7epOu3yA0cQJwxx8dj_Pvrqc_7ld_cmyckoXyZZg0ZdBRuCUJWtr6YeQugfhFyrgQ</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Catov, J M.</creator><creator>Bodnar, L M.</creator><creator>Hackney, D</creator><creator>Roberts, J M.</creator><creator>Simhan, H N.</creator><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20081101</creationdate><title>Activation of the Fibrinolytic Cascade Early in Pregnancy Among Women With Spontaneous Preterm Birth</title><author>Catov, J M. ; Bodnar, L M. ; Hackney, D ; Roberts, J M. ; Simhan, H N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4812-5ceb685c9a6895ed819f1b8b3f68844f90f8cd5b6d0deff25a350e03a1b4f6753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antithrombin III</topic><topic>Biological and medical sciences</topic><topic>C-Reactive Protein - analysis</topic><topic>Case-Control Studies</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Fibrinolysis</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Odds Ratio</topic><topic>Peptide Hydrolases - blood</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second - blood</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Premature Birth - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Catov, J M.</creatorcontrib><creatorcontrib>Bodnar, L M.</creatorcontrib><creatorcontrib>Hackney, D</creatorcontrib><creatorcontrib>Roberts, J M.</creatorcontrib><creatorcontrib>Simhan, H N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Catov, J M.</au><au>Bodnar, L M.</au><au>Hackney, D</au><au>Roberts, J M.</au><au>Simhan, H N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of the Fibrinolytic Cascade Early in Pregnancy Among Women With Spontaneous Preterm Birth</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>112</volume><issue>5</issue><spage>1116</spage><epage>1122</epage><pages>1116-1122</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>To evaluate the association of early pregnancy concentrations of thrombin-antithrombin III complex with subsequent spontaneous preterm birth.
In a nested case-control study, thrombin-antithrombin III complex was measured in plasma before 20 weeks of gestation (mean 9.9 weeks) among women without chronic conditions, preeclampsia, or growth restriction. C-reactive protein and non-high-density lipoprotein cholesterol were also measured. Women with spontaneous preterm birth before 34 weeks of gestation (n=29) and 34 weeks to 36 weeks of gestation (n=72) were compared with women with term births occurring at or after 37 weeks (n=219). Polychotomous logistic regression was used to relate elevated thrombin-antithrombin III complex (greater than 5.5 ng/mL), dyslipidemia (non-high-density lipoprotein cholesterol greater than the 90th percentile), and inflammation (C-reactive protein at or above 8 micrograms/mL) to risk of spontaneous preterm birth subtypes.
Women with spontaneous preterm birth compared with term births had elevated thrombin-antithrombin III complex (P=.02), and they were more likely to have a thrombin-antithrombin III complex greater than 5.5 ng/mL (P<.01). Women with thrombin-antithrombin III complex in the highest compared with lowest quartile had a 4.6-fold (95% confidence interval 1.3-15.8) increased risk for spontaneous preterm birth before 34 weeks of gestation, adjusted for body mass index, race, inflammation, dyslipidemia, and gestational age at sampling. There was a dose-response trend between thrombin-antithrombin III complex and spontaneous preterm birth before 34 weeks (P<.01) and 34 to 36 weeks (P=.03).
There is evidence of early pregnancy systemic fibrinolysis among women with spontaneous preterm birth before 34 weeks of gestation independent of inflammation and dyslipidemia, perhaps secondary to microvascular injury.
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| ispartof | Obstetrics and gynecology (New York. 1953), 2008-11, Vol.112 (5), p.1116-1122 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Antithrombin III Biological and medical sciences C-Reactive Protein - analysis Case-Control Studies Diseases of mother, fetus and pregnancy Female Fibrinolysis Gynecology. Andrology. Obstetrics Humans Medical sciences Odds Ratio Peptide Hydrolases - blood Pregnancy Pregnancy Trimester, Second - blood Pregnancy. Fetus. Placenta Premature Birth - blood Young Adult |
| title | Activation of the Fibrinolytic Cascade Early in Pregnancy Among Women With Spontaneous Preterm Birth |
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