Identification of mitochondrial genome concatemers in AIDS-associated lymphomas and lymphoid cell lines

Abstract Since most oncogenic viruses persist as extrachromosomal covalently closed circular DNA (cccDNA) in tumor cells, we developed an assay to visualize and identify cccDNA in primary lymphomas. We identified concatemers of the mitochondrial genome in all samples analyzed, but not in normal lymp...

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Veröffentlicht in:	Leukemia research 2009-11, Vol.33 (11), p.1499-1504
Hauptverfasser:	Bedoya, Felipe, Medveczky, Maria M, Lund, Troy C, Perl, Andras, Horvath, Joseph, Jett, Stephen D, Medveczky, Peter G
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS-associated lymphomas Base Sequence Cell Line, Tumor DNA Primers DNA, Mitochondrial - genetics Hematology, Oncology and Palliative Medicine Humans Leukemogenesis Lymphoma, AIDS-Related - genetics Lymphoma, AIDS-Related - pathology Microscopy, Electron Mitochondria Mitochondrial DNA concatemers Oncogenic transformation Polymerase Chain Reaction
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