Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse

Protein therapeutics may be delivered across the blood-brain barrier (BBB) by genetic fusion to a BBB molecular Trojan horse. The latter is an endogenous peptide or a peptidomimetic monoclonal antibody (MAb) against a BBB receptor, such as the insulin receptor or the transferrin receptor (TfR). Fusi...

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Veröffentlicht in:	Biotechnology and bioengineering 2009-03, Vol.102 (4), p.1251-1258
Hauptverfasser:	Boado, Ruben J, Zhang, Yun, Wang, Yuntao, Pardridge, William M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - genetics Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacokinetics avidin Biological and medical sciences Biotechnology Blood blood-brain barrier Blood-Brain Barrier - immunology Blood-Brain Barrier - metabolism Brain Brain Chemistry Cercopithecus aethiops Cloning COS Cells drug targeting Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Gene expression Mice Mice, Inbred BALB C Monoclonal antibodies Peptides Protein Binding Proteins Receptors, Transferrin - immunology Receptors, Transferrin - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacokinetics Rodents siRNA transferrin receptor
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