Th9 and allergic disease
Helper CD4⁺ T-cell subsets have improved our understanding of adaptive immunity in humans and in animal models of disease. These include T helper type 1 (Th1), Th2 and the interleukin-17 (IL-17) -producing population 'Th17'. Th2 cells have been described as orchestrating the immune respons...
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| Veröffentlicht in: | Immunology 2009-08, Vol.127 (4), p.450-458 |
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| container_title | Immunology |
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| creator | Soroosh, Pejman Doherty, Taylor A |
| description | Helper CD4⁺ T-cell subsets have improved our understanding of adaptive immunity in humans and in animal models of disease. These include T helper type 1 (Th1), Th2 and the interleukin-17 (IL-17) -producing population 'Th17'. Th2 cells have been described as orchestrating the immune response in allergic disease based on studies with patient samples and animal models. The cytokine IL-9 has largely been regarded as a Th2 cytokine that makes multifocal contributions to allergic disease. Recent data suggest that under certain conditions relevant to chronic disease (IL-4 and transforming growth factor-β), a distinct population of IL-9-producing 'Th9' helper T cells can exist. The contribution of Th9 cells in allergic disease is currently unknown, and this review will propose a model for how these cells may regulate chronic allergic inflammation. |
| doi_str_mv | 10.1111/j.1365-2567.2009.03114.x |
| format | Article |
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The contribution of Th9 cells in allergic disease is currently unknown, and this review will propose a model for how these cells may regulate chronic allergic inflammation.</description><subject>airway remodeling</subject><subject>allergy</subject><subject>Animals</subject><subject>asthma</subject><subject>Asthma - immunology</subject><subject>Asthma - pathology</subject><subject>Disease Models, Animal</subject><subject>Humans</subject><subject>hypersensitivity</subject><subject>Hypersensitivity - immunology</subject><subject>IL-9</subject><subject>Interleukin-9 - biosynthesis</subject><subject>Mice</subject><subject>Review articles</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>TGF‐beta</subject><subject>Th2</subject><subject>Th2 Cells - immunology</subject><subject>transforming growth factor beta</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctPAjEQxhujEXzcPSknb7t2-qQHTQzxQQLxIJwnpduFJQuLW1D4790VgnrSXqbNfN-X6W8IaQGNoTo30xi4khGTSseMUhNTDiDi9QFp7huHpEkpmIi1qWyQkxCm1ZNTKY9JA4yighnTJBeDiWnZedKyee7LceZaSRa8Df6MHKU2D_58V0_J8PFh0HmOei9P3c59L3LScBGlVkI7VYm1zCfcUwCpOGihjEmksU6ptnCGOjHyWllwMhEpUM80syCllvyU3G1zF6vRzCfOz5elzXFRZjNbbrCwGf7uzLMJjot3rCKMZKwKuN4FlMXbyoclzrLgfJ7buS9WAZUWhjMQfwoZZUC1roXtrdCVRQilT_fTAMWaP06xxow1Zqz54xd_XFfWy5-_-TbugFeC263gI8v95t_B2O3361vlv9r6U1ugHZdZwOErqxcLqqKhgX8CHsWa6A</recordid><startdate>200908</startdate><enddate>200908</enddate><creator>Soroosh, Pejman</creator><creator>Doherty, Taylor A</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Blackwell Science Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200908</creationdate><title>Th9 and allergic disease</title><author>Soroosh, Pejman ; Doherty, Taylor A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5934-fa518f6daa2ed3e011563174699d59ac6684c90c4be76a1c5d4f10e272a155753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>airway remodeling</topic><topic>allergy</topic><topic>Animals</topic><topic>asthma</topic><topic>Asthma - immunology</topic><topic>Asthma - pathology</topic><topic>Disease Models, Animal</topic><topic>Humans</topic><topic>hypersensitivity</topic><topic>Hypersensitivity - immunology</topic><topic>IL-9</topic><topic>Interleukin-9 - biosynthesis</topic><topic>Mice</topic><topic>Review articles</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>TGF‐beta</topic><topic>Th2</topic><topic>Th2 Cells - immunology</topic><topic>transforming growth factor beta</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soroosh, Pejman</creatorcontrib><creatorcontrib>Doherty, Taylor A</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soroosh, Pejman</au><au>Doherty, Taylor A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Th9 and allergic disease</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>2009-08</date><risdate>2009</risdate><volume>127</volume><issue>4</issue><spage>450</spage><epage>458</epage><pages>450-458</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><abstract>Helper CD4⁺ T-cell subsets have improved our understanding of adaptive immunity in humans and in animal models of disease. 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| source | MEDLINE; Wiley Free Content; IngentaConnect Open Access Journals; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; PubMed Central |
| subjects | airway remodeling allergy Animals asthma Asthma - immunology Asthma - pathology Disease Models, Animal Humans hypersensitivity Hypersensitivity - immunology IL-9 Interleukin-9 - biosynthesis Mice Review articles T-Lymphocyte Subsets - immunology TGF‐beta Th2 Th2 Cells - immunology transforming growth factor beta |
| title | Th9 and allergic disease |
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