Analysis of the Olfactory Mucosa in Chronic Rhinosinusitis
The impact of chronic rhinosinusitis (CRS) on the olfactory mucosa (OM) is dramatic. Cellular profiles and epithelial integrity in OM biopsies were evaluated using histological and immunohistochemical methods to define a strategy for future histological studies of CRS. We have examined nasal biopsie...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2009-07, Vol.1170 (1), p.590-595 |
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| creator | Yee, Karen K. Pribitkin, Edmund A. Cowart, Beverly J. Rosen, David Feng, Pu Rawson, Nancy E. |
| description | The impact of chronic rhinosinusitis (CRS) on the olfactory mucosa (OM) is dramatic. Cellular profiles and epithelial integrity in OM biopsies were evaluated using histological and immunohistochemical methods to define a strategy for future histological studies of CRS. We have examined nasal biopsies of 54 CRS patients (18–63 years old) and have defined specific histopathological patterns of the OM: normal pseudostratified, goblet cell hyperplasia, squamous metaplasia, and erosion. Goblet cell hyperplasia was most similar to a normal pseudostratified OM pattern but with goblet cells intermixed in the apical layers. Squamous metaplasia exhibited an absence of olfactory supporting cells and had olfactory sensory neurons that were morphologically abnormal. It is unknown if these neurons would be functional in this type of tissue transformation. The pattern of erosion exhibited a severe loss of epithelial layers and a higher prevalence of infiltrating inflammatory cells within the olfactory epithelium when compared to the other OM patterns. Although it is not known if the OM patterns we have noted correspond to specific stages or distinct pathways of the disease, the template proposed here can be used in further studies to understand how the histopathological progression of CRS relates to olfactory loss and the response to treatment. |
| doi_str_mv | 10.1111/j.1749-6632.2009.04364.x |
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Cellular profiles and epithelial integrity in OM biopsies were evaluated using histological and immunohistochemical methods to define a strategy for future histological studies of CRS. We have examined nasal biopsies of 54 CRS patients (18–63 years old) and have defined specific histopathological patterns of the OM: normal pseudostratified, goblet cell hyperplasia, squamous metaplasia, and erosion. Goblet cell hyperplasia was most similar to a normal pseudostratified OM pattern but with goblet cells intermixed in the apical layers. Squamous metaplasia exhibited an absence of olfactory supporting cells and had olfactory sensory neurons that were morphologically abnormal. It is unknown if these neurons would be functional in this type of tissue transformation. The pattern of erosion exhibited a severe loss of epithelial layers and a higher prevalence of infiltrating inflammatory cells within the olfactory epithelium when compared to the other OM patterns. 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Cellular profiles and epithelial integrity in OM biopsies were evaluated using histological and immunohistochemical methods to define a strategy for future histological studies of CRS. We have examined nasal biopsies of 54 CRS patients (18–63 years old) and have defined specific histopathological patterns of the OM: normal pseudostratified, goblet cell hyperplasia, squamous metaplasia, and erosion. Goblet cell hyperplasia was most similar to a normal pseudostratified OM pattern but with goblet cells intermixed in the apical layers. Squamous metaplasia exhibited an absence of olfactory supporting cells and had olfactory sensory neurons that were morphologically abnormal. It is unknown if these neurons would be functional in this type of tissue transformation. The pattern of erosion exhibited a severe loss of epithelial layers and a higher prevalence of infiltrating inflammatory cells within the olfactory epithelium when compared to the other OM patterns. Although it is not known if the OM patterns we have noted correspond to specific stages or distinct pathways of the disease, the template proposed here can be used in further studies to understand how the histopathological progression of CRS relates to olfactory loss and the response to treatment.</description><subject>Chronic Disease</subject><subject>clinical</subject><subject>histopathology</subject><subject>Humans</subject><subject>olfactory epithelium</subject><subject>Olfactory Mucosa - pathology</subject><subject>Rhinitis - pathology</subject><subject>Sinusitis - pathology</subject><issn>0077-8923</issn><issn>1749-6632</issn><issn>1930-6547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkuP0zAURi0EYsrAX0BZsUu4fsQPFqBOBQVp2pF4CLGyHMehLmk82Am0_550WhVYTb25lu65Z_HpQyjDUODxvVwXWDCVc05JQQBUAYxyVmwfoMlp8RBNAITIpSL0Aj1JaQ2AiWTiMbrAikuOlZygV9POtLvkUxaarF-57KZtjO1D3GWLwYZkMt9ls1UMnbfZx5XvQvLdkHzv01P0qDFtcs-O8xJ9eff28-x9fn0z_zCbXudWAGG5U7UEaQgwzog0tmRlXVdSOcFVBRWuDKsrgilzwBU0hGCLZV0y4mzNHeH0Er0-eG-HauNq67o-mlbfRr8xcaeD8fr_TedX-nv4pYkgqgQ5Cl4cBTH8HFzq9cYn69rWdC4MSXNRSoyVuhekTAjF2f1GAkIBoeIcUBIo4RxQSMXLEZQH0MaQUnTNKQgMel8Ovdb7Duh9B_S-HPquHHo7nj7_N8i_h8c2jMCbA_Dbt253tlgvv00_3f1HQ34w-NS77clg4o8xZSpK_XU51wsG84W6WmpJ_wCN3dcz</recordid><startdate>200907</startdate><enddate>200907</enddate><creator>Yee, Karen K.</creator><creator>Pribitkin, Edmund A.</creator><creator>Cowart, Beverly J.</creator><creator>Rosen, David</creator><creator>Feng, Pu</creator><creator>Rawson, Nancy E.</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SP</scope><scope>7U5</scope><scope>L7M</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200907</creationdate><title>Analysis of the Olfactory Mucosa in Chronic Rhinosinusitis</title><author>Yee, Karen K. ; Pribitkin, Edmund A. ; Cowart, Beverly J. ; Rosen, David ; Feng, Pu ; Rawson, Nancy E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c7024-e9d808a2046428ac545ddb89e769b0b1ba4db2134e0690f221c18d542ecd6e263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Chronic Disease</topic><topic>clinical</topic><topic>histopathology</topic><topic>Humans</topic><topic>olfactory epithelium</topic><topic>Olfactory Mucosa - pathology</topic><topic>Rhinitis - pathology</topic><topic>Sinusitis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yee, Karen K.</creatorcontrib><creatorcontrib>Pribitkin, Edmund A.</creatorcontrib><creatorcontrib>Cowart, Beverly J.</creatorcontrib><creatorcontrib>Rosen, David</creatorcontrib><creatorcontrib>Feng, Pu</creatorcontrib><creatorcontrib>Rawson, Nancy E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yee, Karen K.</au><au>Pribitkin, Edmund A.</au><au>Cowart, Beverly J.</au><au>Rosen, David</au><au>Feng, Pu</au><au>Rawson, Nancy E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the Olfactory Mucosa in Chronic Rhinosinusitis</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2009-07</date><risdate>2009</risdate><volume>1170</volume><issue>1</issue><spage>590</spage><epage>595</epage><pages>590-595</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><eissn>1930-6547</eissn><abstract>The impact of chronic rhinosinusitis (CRS) on the olfactory mucosa (OM) is dramatic. Cellular profiles and epithelial integrity in OM biopsies were evaluated using histological and immunohistochemical methods to define a strategy for future histological studies of CRS. We have examined nasal biopsies of 54 CRS patients (18–63 years old) and have defined specific histopathological patterns of the OM: normal pseudostratified, goblet cell hyperplasia, squamous metaplasia, and erosion. Goblet cell hyperplasia was most similar to a normal pseudostratified OM pattern but with goblet cells intermixed in the apical layers. Squamous metaplasia exhibited an absence of olfactory supporting cells and had olfactory sensory neurons that were morphologically abnormal. It is unknown if these neurons would be functional in this type of tissue transformation. The pattern of erosion exhibited a severe loss of epithelial layers and a higher prevalence of infiltrating inflammatory cells within the olfactory epithelium when compared to the other OM patterns. 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| subjects | Chronic Disease clinical histopathology Humans olfactory epithelium Olfactory Mucosa - pathology Rhinitis - pathology Sinusitis - pathology |
| title | Analysis of the Olfactory Mucosa in Chronic Rhinosinusitis |
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