Cutaneous allodynia in the migraine population
Objective To develop and validate a questionnaire for assessing cutaneous allodynia (CA), and to estimate the prevalence and severity of CA in the migraine population. Methods Migraineurs (n = 11,388) completed the Allodynia Symptom Checklist, assessing the frequency of allodynia symptoms during hea...
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| Veröffentlicht in: | Annals of neurology 2008-02, Vol.63 (2), p.148-158 |
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| creator | Lipton, Richard B. Bigal, Marcelo E. Ashina, Sait Burstein, Rami Silberstein, Stephen Reed, Michael L. Serrano, Daniel Stewart, Walter F. |
| description | Objective
To develop and validate a questionnaire for assessing cutaneous allodynia (CA), and to estimate the prevalence and severity of CA in the migraine population.
Methods
Migraineurs (n = 11,388) completed the Allodynia Symptom Checklist, assessing the frequency of allodynia symptoms during headache. Response options were never (0), rarely (0), less than 50% of the time (1), ≥50% of the time (2), and none (0). We used item response theory to explore how well each item discriminated CA. The relations of CA to headache features were examined.
Results
All 12 questions had excellent item properties. The greatest discrimination occurred with CA during “taking a shower” (discrimination = 2.54), wearing a necklace (2.39) or ring (2.31), and exposure to heat (2.1) or cold (2.0). The factor analysis demonstrated three factors: thermal, mechanical static, and mechanical dynamic. Based on the psychometrics, we developed a scale distinguishing no CA (scores 0–2), mild (3–5), moderate (6–8), and severe (≥9). The prevalence of allodynia among migraineurs was 63.2%. Severe CA occurred in 20.4% of migraineurs. CA was associated with migraine defining features (eg, unilateral pain: odds ratio, 2.3; 95% confidence interval, 2.0–2.4; throbbing pain: odds ratio, 2.3; 95% confidence interval, 2.1–2.6; nausea: odds ratio, 2.3; 95% confidence interval, 2.1–2.6), as well as illness duration, attack frequency, and disability.
Interpretation
The Allodynia Symptom Checklist measures overall allodynia and subtypes. CA affects 63% of migraineurs in the population and is associated with frequency, severity, disability, and associated symptoms of migraine. CA maps onto migraine biology. Ann Neurol 2007 |
| doi_str_mv | 10.1002/ana.21211 |
| format | Article |
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To develop and validate a questionnaire for assessing cutaneous allodynia (CA), and to estimate the prevalence and severity of CA in the migraine population.
Methods
Migraineurs (n = 11,388) completed the Allodynia Symptom Checklist, assessing the frequency of allodynia symptoms during headache. Response options were never (0), rarely (0), less than 50% of the time (1), ≥50% of the time (2), and none (0). We used item response theory to explore how well each item discriminated CA. The relations of CA to headache features were examined.
Results
All 12 questions had excellent item properties. The greatest discrimination occurred with CA during “taking a shower” (discrimination = 2.54), wearing a necklace (2.39) or ring (2.31), and exposure to heat (2.1) or cold (2.0). The factor analysis demonstrated three factors: thermal, mechanical static, and mechanical dynamic. Based on the psychometrics, we developed a scale distinguishing no CA (scores 0–2), mild (3–5), moderate (6–8), and severe (≥9). The prevalence of allodynia among migraineurs was 63.2%. Severe CA occurred in 20.4% of migraineurs. CA was associated with migraine defining features (eg, unilateral pain: odds ratio, 2.3; 95% confidence interval, 2.0–2.4; throbbing pain: odds ratio, 2.3; 95% confidence interval, 2.1–2.6; nausea: odds ratio, 2.3; 95% confidence interval, 2.1–2.6), as well as illness duration, attack frequency, and disability.
Interpretation
The Allodynia Symptom Checklist measures overall allodynia and subtypes. CA affects 63% of migraineurs in the population and is associated with frequency, severity, disability, and associated symptoms of migraine. CA maps onto migraine biology. Ann Neurol 2007</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.21211</identifier><identifier>PMID: 18059010</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Biomarkers - analysis ; Cohort Studies ; Comorbidity ; Data Interpretation, Statistical ; Disease Progression ; Early Diagnosis ; Female ; Humans ; Hyperalgesia - epidemiology ; Hyperalgesia - physiopathology ; Male ; Medical sciences ; Middle Aged ; Migraine Disorders - diagnosis ; Migraine Disorders - epidemiology ; Migraine Disorders - physiopathology ; Neurology ; Nociceptors - physiopathology ; Pain Measurement - methods ; Pain Threshold - physiology ; Predictive Value of Tests ; Prognosis ; Sensory Receptor Cells - physiopathology ; Severity of Illness Index ; Skin - innervation ; Skin - physiopathology ; Surveys and Questionnaires ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Annals of neurology, 2008-02, Vol.63 (2), p.148-158</ispartof><rights>Copyright © 2007 American Neurological Association</rights><rights>2008 INIST-CNRS</rights><rights>2007 American Neurological Association 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5071-faae7fb54b8982492a7322ad819ca85d18044b3b2599c6eb8c3b1813ff48a5bf3</citedby><cites>FETCH-LOGICAL-c5071-faae7fb54b8982492a7322ad819ca85d18044b3b2599c6eb8c3b1813ff48a5bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.21211$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.21211$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20162887$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18059010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lipton, Richard B.</creatorcontrib><creatorcontrib>Bigal, Marcelo E.</creatorcontrib><creatorcontrib>Ashina, Sait</creatorcontrib><creatorcontrib>Burstein, Rami</creatorcontrib><creatorcontrib>Silberstein, Stephen</creatorcontrib><creatorcontrib>Reed, Michael L.</creatorcontrib><creatorcontrib>Serrano, Daniel</creatorcontrib><creatorcontrib>Stewart, Walter F.</creatorcontrib><creatorcontrib>American Migraine Prevalence Prevention Advisory Group</creatorcontrib><title>Cutaneous allodynia in the migraine population</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Objective
To develop and validate a questionnaire for assessing cutaneous allodynia (CA), and to estimate the prevalence and severity of CA in the migraine population.
Methods
Migraineurs (n = 11,388) completed the Allodynia Symptom Checklist, assessing the frequency of allodynia symptoms during headache. Response options were never (0), rarely (0), less than 50% of the time (1), ≥50% of the time (2), and none (0). We used item response theory to explore how well each item discriminated CA. The relations of CA to headache features were examined.
Results
All 12 questions had excellent item properties. The greatest discrimination occurred with CA during “taking a shower” (discrimination = 2.54), wearing a necklace (2.39) or ring (2.31), and exposure to heat (2.1) or cold (2.0). The factor analysis demonstrated three factors: thermal, mechanical static, and mechanical dynamic. Based on the psychometrics, we developed a scale distinguishing no CA (scores 0–2), mild (3–5), moderate (6–8), and severe (≥9). The prevalence of allodynia among migraineurs was 63.2%. Severe CA occurred in 20.4% of migraineurs. CA was associated with migraine defining features (eg, unilateral pain: odds ratio, 2.3; 95% confidence interval, 2.0–2.4; throbbing pain: odds ratio, 2.3; 95% confidence interval, 2.1–2.6; nausea: odds ratio, 2.3; 95% confidence interval, 2.1–2.6), as well as illness duration, attack frequency, and disability.
Interpretation
The Allodynia Symptom Checklist measures overall allodynia and subtypes. CA affects 63% of migraineurs in the population and is associated with frequency, severity, disability, and associated symptoms of migraine. CA maps onto migraine biology. Ann Neurol 2007</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Data Interpretation, Statistical</subject><subject>Disease Progression</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperalgesia - epidemiology</subject><subject>Hyperalgesia - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Migraine Disorders - diagnosis</subject><subject>Migraine Disorders - epidemiology</subject><subject>Migraine Disorders - physiopathology</subject><subject>Neurology</subject><subject>Nociceptors - physiopathology</subject><subject>Pain Measurement - methods</subject><subject>Pain Threshold - physiology</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Sensory Receptor Cells - physiopathology</subject><subject>Severity of Illness Index</subject><subject>Skin - innervation</subject><subject>Skin - physiopathology</subject><subject>Surveys and Questionnaires</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFv0zAUxy0EYmXswBdAuTCJQzo_O07sC1JXsQ1tGhdYj9aL62zeXKezE6DfnpSUMg47-eDf-__f-xHyDugUKGUnGHDKgAG8IBMQHHLJCvWSTCgvi1wALw7Im5TuKaWqBPqaHICkQlGgEzKd9x0G2_YpQ-_b5SY4zFzIujubrdxtRBdstm7XvcfOteEtedWgT_Zo9x6S72efv80v8quv51_ms6vcCFpB3iDaqqlFUUu13YVhxRnDpQRlUIrl0F8UNa-ZUMqUtpaG1yCBN00hUdQNPySfxtx1X6_s0tjQRfR6Hd0K40a36PT_P8Hd6dv2h2YVU4USQ8DxLiC2j71NnV65ZKz347G6GtxwxrfgxxE0sU0p2mZfAlRv7erBrv5jd2DfP93qH7nTOQAfdgAmg76JGIxLe45RKJmU1cCdjNxP5-3m-UY9u579rc7HCZc6-2s_gfFBlxWvhF5cn-tLdXO2WFye6gv-G93DoBk</recordid><startdate>200802</startdate><enddate>200802</enddate><creator>Lipton, Richard B.</creator><creator>Bigal, Marcelo E.</creator><creator>Ashina, Sait</creator><creator>Burstein, Rami</creator><creator>Silberstein, Stephen</creator><creator>Reed, Michael L.</creator><creator>Serrano, Daniel</creator><creator>Stewart, Walter F.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200802</creationdate><title>Cutaneous allodynia in the migraine population</title><author>Lipton, Richard B. ; Bigal, Marcelo E. ; Ashina, Sait ; Burstein, Rami ; Silberstein, Stephen ; Reed, Michael L. ; Serrano, Daniel ; Stewart, Walter F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5071-faae7fb54b8982492a7322ad819ca85d18044b3b2599c6eb8c3b1813ff48a5bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Data Interpretation, Statistical</topic><topic>Disease Progression</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperalgesia - epidemiology</topic><topic>Hyperalgesia - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Migraine Disorders - diagnosis</topic><topic>Migraine Disorders - epidemiology</topic><topic>Migraine Disorders - physiopathology</topic><topic>Neurology</topic><topic>Nociceptors - physiopathology</topic><topic>Pain Measurement - methods</topic><topic>Pain Threshold - physiology</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Sensory Receptor Cells - physiopathology</topic><topic>Severity of Illness Index</topic><topic>Skin - innervation</topic><topic>Skin - physiopathology</topic><topic>Surveys and Questionnaires</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lipton, Richard B.</creatorcontrib><creatorcontrib>Bigal, Marcelo E.</creatorcontrib><creatorcontrib>Ashina, Sait</creatorcontrib><creatorcontrib>Burstein, Rami</creatorcontrib><creatorcontrib>Silberstein, Stephen</creatorcontrib><creatorcontrib>Reed, Michael L.</creatorcontrib><creatorcontrib>Serrano, Daniel</creatorcontrib><creatorcontrib>Stewart, Walter F.</creatorcontrib><creatorcontrib>American Migraine Prevalence Prevention Advisory Group</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lipton, Richard B.</au><au>Bigal, Marcelo E.</au><au>Ashina, Sait</au><au>Burstein, Rami</au><au>Silberstein, Stephen</au><au>Reed, Michael L.</au><au>Serrano, Daniel</au><au>Stewart, Walter F.</au><aucorp>American Migraine Prevalence Prevention Advisory Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cutaneous allodynia in the migraine population</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2008-02</date><risdate>2008</risdate><volume>63</volume><issue>2</issue><spage>148</spage><epage>158</epage><pages>148-158</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>Objective
To develop and validate a questionnaire for assessing cutaneous allodynia (CA), and to estimate the prevalence and severity of CA in the migraine population.
Methods
Migraineurs (n = 11,388) completed the Allodynia Symptom Checklist, assessing the frequency of allodynia symptoms during headache. Response options were never (0), rarely (0), less than 50% of the time (1), ≥50% of the time (2), and none (0). We used item response theory to explore how well each item discriminated CA. The relations of CA to headache features were examined.
Results
All 12 questions had excellent item properties. The greatest discrimination occurred with CA during “taking a shower” (discrimination = 2.54), wearing a necklace (2.39) or ring (2.31), and exposure to heat (2.1) or cold (2.0). The factor analysis demonstrated three factors: thermal, mechanical static, and mechanical dynamic. Based on the psychometrics, we developed a scale distinguishing no CA (scores 0–2), mild (3–5), moderate (6–8), and severe (≥9). The prevalence of allodynia among migraineurs was 63.2%. Severe CA occurred in 20.4% of migraineurs. CA was associated with migraine defining features (eg, unilateral pain: odds ratio, 2.3; 95% confidence interval, 2.0–2.4; throbbing pain: odds ratio, 2.3; 95% confidence interval, 2.1–2.6; nausea: odds ratio, 2.3; 95% confidence interval, 2.1–2.6), as well as illness duration, attack frequency, and disability.
Interpretation
The Allodynia Symptom Checklist measures overall allodynia and subtypes. CA affects 63% of migraineurs in the population and is associated with frequency, severity, disability, and associated symptoms of migraine. CA maps onto migraine biology. Ann Neurol 2007</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>18059010</pmid><doi>10.1002/ana.21211</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of neurology, 2008-02, Vol.63 (2), p.148-158 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Biological and medical sciences Biomarkers - analysis Cohort Studies Comorbidity Data Interpretation, Statistical Disease Progression Early Diagnosis Female Humans Hyperalgesia - epidemiology Hyperalgesia - physiopathology Male Medical sciences Middle Aged Migraine Disorders - diagnosis Migraine Disorders - epidemiology Migraine Disorders - physiopathology Neurology Nociceptors - physiopathology Pain Measurement - methods Pain Threshold - physiology Predictive Value of Tests Prognosis Sensory Receptor Cells - physiopathology Severity of Illness Index Skin - innervation Skin - physiopathology Surveys and Questionnaires Vascular diseases and vascular malformations of the nervous system |
| title | Cutaneous allodynia in the migraine population |
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