Glutamatergic Neuronal Differentiation of Mouse Embryonic Stem Cells after Transient Expression of Neurogenin 1 and Treatment with BDNF and GDNF: In Vitro and In Vivo Studies

Differentiation of the pluripotent neuroepithelium into neurons and glia is accomplished by the interaction of growth factors and cell-type restricted transcription factors. One approach to obtaining a particular neuronal phenotype is by recapitulating the expression of these factors in embryonic st...

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Veröffentlicht in:	The Journal of neuroscience 2008-11, Vol.28 (48), p.12622-12631
Hauptverfasser:	Reyes, Jeannie H, O'Shea, K. Sue, Wys, Noel L, Velkey, J. Matthew, Prieskorn, Diane M, Wesolowski, Karolina, Miller, Josef M, Altschuler, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Biomarkers - analysis Biomarkers - metabolism Brain-Derived Neurotrophic Factor - metabolism Brain-Derived Neurotrophic Factor - pharmacology Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line Cells, Cultured Cochlear Nerve - drug effects Cochlear Nerve - embryology Cochlear Nerve - metabolism Deafness - chemically induced Deafness - metabolism Deafness - surgery Doxycycline - pharmacology Embryonic Stem Cells - drug effects Embryonic Stem Cells - metabolism Embryonic Stem Cells - transplantation Glial Cell Line-Derived Neurotrophic Factor - metabolism Glial Cell Line-Derived Neurotrophic Factor - pharmacology Glutamic Acid - metabolism Guinea Pigs Humans Mice Nerve Growth Factors - metabolism Nerve Growth Factors - pharmacology Nerve Tissue Proteins - drug effects Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurogenesis - drug effects Neurogenesis - physiology Phenotype Sensory Receptor Cells - drug effects Sensory Receptor Cells - metabolism Stem Cell Transplantation - methods
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