Axon Regeneration Requires a Conserved MAP Kinase Pathway

Regeneration of injured neurons can restore function, but most neurons regenerate poorly or not at all. The failure to regenerate in some cases is due to a lack of activation of cell-intrinsic regeneration pathways. These pathways might be targeted for the development of therapies that can restore n...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2009-02, Vol.323 (5915), p.802-806
Hauptverfasser:	Hammarlund, Marc, Nix, Paola, Hauth, Linda, Jorgensen, Erik M, Bastiani, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Axons Axons - physiology Axons - ultrastructure Axotomy Biological and medical sciences Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cellular biology Developmental biology Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Growth cones Growth Cones - physiology Kinases MAP Kinase Kinase 4 - genetics MAP Kinase Kinase 4 - metabolism MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism MAP Kinase Signaling System Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism Models, Biological Motor Neurons - physiology Mutation Nematodes Nerve Regeneration - physiology Neurology Neurons Neuroscience Physical trauma Pseudopodia Regeneration RNA Interference Shock heating Vertebrates: nervous system and sense organs
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