Plasminogen activator inhibitors regulate cell adhesion through a uPAR-dependent mechanism

Binding of type‐1 plasminogen activator inhibitor (PAI‐1) to cell surface urokinase (uPA) promotes inactivation and internalization of adhesion receptors (e.g., urokinase receptor (uPAR), integrins) and leads to cell detachment from a variety of extracellular matrices. In this report, we begin to ex...

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Veröffentlicht in:	Journal of cellular physiology 2009-09, Vol.220 (3), p.655-663
Hauptverfasser:	Czekay, Ralf-Peter, Loskutoff, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Protein Precursor - metabolism Animals Antibodies, Monoclonal Cell Adhesion Cell Line, Tumor Endocytosis Extracellular Matrix - metabolism Fibronectins - metabolism Humans Integrin alpha3 - metabolism Mice Mutation Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - metabolism Protease Nexins Receptors, Cell Surface - metabolism Receptors, Urokinase Plasminogen Activator - genetics Receptors, Urokinase Plasminogen Activator - immunology Receptors, Urokinase Plasminogen Activator - metabolism Recombinant Proteins - metabolism Serpin E2 Transfection Urokinase-Type Plasminogen Activator - metabolism Vitronectin - metabolism
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