A Screen for Modifiers of Notch Signaling Uncovers Amun, a Protein With a Critical Role in Sensory Organ Development

Notch signaling is an evolutionarily conserved pathway essential for many cell fate specification events during metazoan development. We conducted a large-scale transposon-based screen in the developing Drosophila eye to identify genes involved in Notch signaling. We screened 10,447 transposon lines...

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Veröffentlicht in:	Genetics (Austin) 2009-08, Vol.182 (4), p.1061-1076
Hauptverfasser:	Shalaby, Nevine A, Parks, Annette L, Morreale, Eric J, Osswalt, Marisa C, Pfau, Kristen M, Pierce, Eric L, Muskavitch, Marc A. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Helix-Loop-Helix Transcription Factors - metabolism Cells DNA Glycosylases - genetics DNA Glycosylases - physiology DNA Transposable Elements Drosophila Proteins - genetics Drosophila Proteins - metabolism Drosophila Proteins - physiology Eye - chemistry Eye - growth & development Genetics Investigations Nuclear Proteins - genetics Nuclear Proteins - physiology Proteins Receptors, Notch - metabolism Sense Organs - chemistry Sense Organs - growth & development Signal Transduction Specifications Transcription Factors - genetics Transcription Factors - physiology
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